Sleep-Related Hypoxia Tied to Incident Atrial Fibrillation
By Lori Solomon HealthDay Reporter
WEDNESDAY, Nov. 22, 2023 -- Sleep-related hypoxia is associated with incident atrial fibrillation (AF), according to a study published online Nov. 10 in the Journal of the American Heart Association.
Catherine M. Heinzinger, D.O., from the Cleveland Clinic, and colleagues examined the association between sleep-disordered breathing, hypoxia, and pulmonary physiology on atrial fibrillation. The analysis included 42,057 patients who underwent sleep studies at a single institution between 2000 and 2015.
The researchers found that 4.6 percent of participants developed AF over five years. An increase of 10 units in the apnea-hypopnea index was associated with a trend toward higher AF risk (hazard ratio, 1.02; 95 percent confidence interval [CI], 1.00 to 1.03). Associations were seen for a 10-unit increase in percentage time oxygen saturation <90 percent and 10-unit decreases in mean and minimum oxygen saturation with higher AF risk (hazard ratios [95 percent CI], 1.06 [1.04 to 1.08], 1.30 [1.18 to 1.42], and 1.09 [1.03 to 1.15], respectively). Among the subset of 9,683 patients with spirometry data, only hypoxia remained significantly associated with incident AF in an adjusted analysis.
"Findings set the stage to better understand hypoxic mechanisms leading to atrial arrhythmia and indicate a potential role for nocturnal supplemental oxygen therapy in prevention of atrial arrhythmogenesis," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted November 2023
Read this next
Disparities in Direct Oral Anticoagulant Initiation Have Declined in Recent Years
FRIDAY, May 10, 2024 -- Historical disparities in initiation of direct oral anticoagulants (DOACs) for atrial fibrillation have lessened for Black and Hispanic patients, according...
A-Fib Patients Younger Than 65 Face Heightened Risk for Heart-Related Hospitalization
TUESDAY, May 7, 2024 -- Patients younger than 65 years with atrial fibrillation (AF) have a significant burden of risk factors and comorbidities, as well as heightened risk for...
Sleep Apnea, Low Oxygen in Sleep Linked to Late-Onset Epilepsy
THURSDAY, May 2, 2024 -- Sleep apnea and late-midlife oxygen desaturation to less than 80 percent during sleep are associated with subsequent development of late-onset epilepsy...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.