Dose Requirements for Glabellar Botulinum Toxin Higher in High-Sun Climate
By Elana Gotkine HealthDay Reporter
FRIDAY, July 19, 2024 -- To achieve maximal paralysis, patients injected with glabellar botulinum toxin may have significantly higher dose requirements in a high sun-exposure environment, according to a study published in the July issue of Plastic and Reconstructive Surgery.
Kim L. Borsky, M.B.B.S., M.D., from the Stoke Mandeville Hospital in the United Kingdom, and colleagues conducted a comparative cohort study using data from a registry from a single provider practicing in the United Kingdom (low sun exposure) and Malta (high sun exposure). Women aged 35 to 60 years undergoing glabellar botulinum toxin treatment following standard procedures from 2012 to 2019 were included; patients received top-up doses until full clinical paralysis was achieved. Data were included for 523 patients: 292 with high sun exposure and 231 with low sun exposure.
The researchers found that the mean total doses were significantly higher in the high versus low sun-exposure group (29.2 versus 27.3 units). The low-sun group still had significantly lower total dose requirements when correcting for age in multivariable analyses.
"Rigid protocols about doses and distributions may lead to undertreatment if applied in sunnier climates," the authors write. "Treatment protocols may need to account for the climate in which treatments are being undertaken to achieve more predictable results."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted July 2024
Read this next
Many U.S. Adults Still Have Misconceptions About Skin Cancer Risk
WEDNESDAY, March 26, 2025 -- About two-thirds of U.S. adults report no sunburns in the past year, with significant associations seen between the number of sunburns and...
One in Six Parents Support Teens Getting Nonsurgical Cosmetic Procedures
FRIDAY, Feb. 28, 2025 -- Few parents say their teen has asked about nonsurgical cosmetic procedures, according to the results of a C.S. Mott Children's Hospital National Poll...
New Facial Plastic Surgery Survey Illustrates Impact of GLP-1 Receptor Agonists
FRIDAY, Feb. 7, 2025 -- Glucagon-like peptide-1 receptor agonist (GLP-1 RA) medications for weight loss are significantly transforming the field of facial plastic surgery...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.