Rate of Positive Laparoscopy High for Patients With Pancreatic Cancer
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
TUESDAY, Aug. 15, 2023 -- For patients with pancreatic ductal adenocarcinoma (PDAC), the rate of positive laparoscopy (PL) is high and is associated with younger age, indeterminate extrapancreatic lesions on preoperative imaging, and body/tail tumor location, according to a study published in the July issue of the Journal of the American College of Surgeons.
Hallbera Gudmundsdottir, M.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues examined the diagnostic yield of staging laparoscopy (SL) and identified factors associated with increased risk of PL in the modern era among 1,004 patients with localized PDAC who underwent SL from 2017 to 2021.
The researchers found that 18 percent of the patients had PL due to gross metastases and/or positive cytology. The rates of PL were lower for patients who had neoadjuvant chemotherapy prior to laparoscopy (14 versus 22 percent). Twenty-three percent of patients had PL when the analysis was restricted to the 419 chemotherapy-naive patients who had concurrent peritoneal lavage performed. In multivariable analysis, there were associations seen for PL with younger age (<60 years), indeterminate extrapancreatic lesions on preoperative imaging, body/tail tumor location, larger tumor size, and elevated serum CA 19-9. The rate of PL ranged among patients with no indeterminate extrapancreatic lesions on preoperative imaging, from 1.6 percent for those with no risk factors to 42 percent in young patients with large body/tail tumors and elevated serum CA 19-9.
"Based on these results, we recommend that staging laparoscopy be performed before starting chemotherapy in the majority of patients who have pancreatic cancer and are being considered for surgery," Gudmundsdottir said in a statement.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted August 2023
Read this next
American Association for Cancer Research, April 5-10
The annual meeting of the American Association for Cancer Research was held this year from April 5 to 10 in San Diego, drawing approximately 19,000 participants from around the...
Subclassification Can Tailor Surveillance for Pancreatic Adenocarcinoma
WEDNESDAY, April 17, 2024 -- Subclassification of individuals at high risk for pancreatic adenocarcinoma (PC) can enable the development of surveillance approaches better tailored...
AACR: Exosome-Based miRNA Assay Can Detect Pancreatic Cancer
MONDAY, April 8, 2024 -- An exosome-based liquid biopsy assay can distinguish patients with pancreatic ductal adenocarcinoma (PDAC) from healthy donors (HDs), according to a study...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.