Psilocybin Promising for Treating Major Depressive Disorder
WEDNESDAY, Nov. 4, 2020 -- Psilocybin in the context of supportive psychotherapy may be effective for treating major depressive disorder (MDD), according to a study published online Nov. 4 in JAMA Psychiatry.
Alan K. Davis, Ph.D., from the Johns Hopkins School of Medicine in Baltimore, and colleagues examined the effect of psilocybin therapy in patients with MDD. Adults aged 21 to 75 years with an MDD diagnosis were eligible to participate: 27 participants were randomly assigned to either an immediate treatment condition group, which received two psilocybin sessions, or delayed treatment condition group (eight-week delay; 15 and 12 participants, respectively).
The researchers found that the mean GRID-Hamilton Depression Rating Scale scores at weeks 1 and 4 in the immediate treatment group were statistically significantly lower than the sores at the comparable time points of weeks 5 and 8 in the delayed treatment group (8.0 and 8.5, respectively, versus 23.8 and 23.5, respectively). At weeks 5 and 8, the effect sizes were large. From baseline to day 1 after session 1, the Quick Inventory of Depressive Symptomatology-Self Rated documented a rapid decrease in mean depression score (16.7 versus 6.3), which remained statistically significantly reduced through week 4 of follow-up (6.0).
"These data expand the findings of previous studies involving patients with cancer and depression as well as patients with treatment-resistant depression by suggesting that psilocybin may be effective in the much larger population of MDD," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.
© 2021 HealthDay. All rights reserved.
Posted: November 2020
Read this next
THURSDAY, Jan. 14, 2021 -- Probable mental health disorders are common among intensive care unit (ICU) staff working in English hospitals during June and July 2020, according to a...
WEDNESDAY, Jan. 13, 2021 -- Lethal means counseling and provision of cable locks result in greater adoption of safe storage methods for firearms, according to a study published...
FRIDAY, Jan. 8, 2021 -- From 2014 to 2017, there was an increase in firearm use among female nurse suicides, according to a study published online Dec. 21 in Nursing Forum. Judy...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.