Skip to main content

Precision-Guided Treatment Improves Outcomes for High-Risk Pediatric Cancer

Medically reviewed by Carmen Pope, BPharm. Last updated on June 28, 2024.

By Elana Gotkine HealthDay Reporter

FRIDAY, June 28, 2024 -- Precision-guided treatment improves outcomes for children with high-risk cancer, according to a study published online June 6 in Nature Medicine.

Loretta M.S. Lau, M.B.B.S., Ph.D., from the Children's Cancer Institute at the University of New South Wales Sydney, and colleagues reported data from 384 patients with high-risk pediatric cancer with at least 18 months of follow-up on the ZERO Childhood Cancer Precision Medicine Program PRecISion Medicine for Children with Cancer trial to examine which patients will benefit most from PGT. Overall, 67 and 29 percent of children received PGT recommendations and received a recommended treatment, respectively.

The researchers found that the objective response rate was 36 percent with PGT, and two-year progression-free survival was improved with PGT versus standard of care or targeted agents not guided by other molecular findings (26 percent versus 12 and 5.2 percent, respectively). Based on tier 1 evidence, the greatest clinical benefit was seen for PGT targeting fusions or commenced before disease progression.

"This study demonstrates that children with high-risk cancers benefit from PGT identified by comprehensive molecular profiling," the authors write. "Treatment strategies should focus on the identification of drivers and early treatment of patients with highly targetable molecular drivers."

Several authors disclosed ties to the pharmaceutical industry.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Read this next

Vitamin D3 Supplementation Reduces Telomere Attrition

MONDAY, June 2, 2025 -- Supplementation with vitamin D3 is associated with reduced telomere attrition in adults aged 50 years and older, according to a study published online May...

Quality of Low-Carb, Low-Fat Diet Affects Heart Disease Risk

MONDAY, June 2, 2025 -- The association of low-carbohydrate (LCD) and low-fat diets (LFD) with coronary heart disease (CHD) risk depends on the quality of macronutrients...

Physical Activity Linked to Better Survival for Specific Cancer Types

FRIDAY, May 30, 2025 -- Engaging in leisure-time moderate- to vigorous-intensity physical activity (MVPA) is associated with better overall survival for participants with a...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.