Obesity Modifies Link Between Birth Weight, Metabolic Phenotypes
By Elana Gotkine HealthDay Reporter
TUESDAY, July 16, 2024 -- Associations between lower birth weight (BW) and adverse metabolic phenotypes are more pronounced in children with obesity, according to a study published in the July issue of eBioMedicine.
Sara Elizabeth Stinson, Ph.D., from the University of Copenhagen in Denmark, and colleagues used data from the cross-sectional HOLBAEK Study with 4,263 participants to examine the modifying effect of childhood obesity on the association between BW and a polygenic score (PGS) for BW with cardiometabolic risk in children and adolescents.
The researchers found that BW and a PGS for BW were associated with cardiometabolic risk and plasma protein levels in childhood and adolescence. The associations between BW and measures of insulin resistance were modified by childhood obesity, including Homeostasis Model Assessment for Insulin Resistance (−0.12 and −0.04 for obesity and normal weight, respectively), c-peptide (−0.11 and −0.02 for obesity and normal weight, respectively), and systolic blood pressure standard deviation score (−0.12 and −0.06 for obesity and normal weight, respectively). The associations between BW and plasma levels of 14 proteins were also modified by childhood obesity.
"This study underlines the importance of early intervention and prevention in the effort to combat the pandemic of obesity and cardiometabolic disease," the authors write.
Several authors disclosed ties to biopharmaceutical companies, including Novo Nordisk, which partially funded the study.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted July 2024
Read this next
Less 'Experienced Weight Stigma' After Bariatric Surgery Aids Mental Health
FRIDAY, June 6, 2025 -- Experienced weight stigma (EWS) improves from pre- to post-metabolic bariatric surgery (MBS), according to a study published online June 5 in Health...
Obesity Linked to Subsequent Neoplasms in Childhood Cancer Survivors
FRIDAY, June 6, 2025 -- Body mass index (BMI) and physical activity are associated with the risk for subsequent neoplasms among childhood cancer survivors, according to a study...
GLP-1 Receptor Agonist Exposure Linked to Neovascular AMD in Patients With Diabetes
FRIDAY, June 6, 2025 -- For patients with diabetes, exposure to glucagon-like peptide-1 receptor agonists (GLP-1 RAs) is associated with an increased risk for incident neovascular...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.