Methylation Score Can ID Risk for Cervical Adenocarcinomas
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
WEDNESDAY, Sept. 13, 2023 -- A methylation score, composed of the average methylation percentage across 35 CpG sites in the L2/L1 open reading frames of human papillomavirus (HPV)16, 18, and 45, and two human loci, can identify the risk for cervical adenocarcinoma (ADC) and adenocarcinoma in situ (AIS), according to a study published online July 19 in the Journal of the National Cancer Institute.
Anna Gradissimo, Ph.D., from the Albert Einstein College of Medicine in Bronx, New York, and colleagues measured methylation levels at CpG sites in HPV16, HPV18, and HPV45, as well as human loci DCC and HS3ST2, to develop a DNA methylation score for AIS and ADC screening. Exfoliated cervicovaginal cells were obtained from women who were positive for either HPV16, 18, or 45: 176 with AIS/ADC and 353 with cervical intraepithelial neoplasia-3 (CIN3) or cervical squamous cell cancer (SCC). Controls who cleared (579 HPV clearers) or had persistent HPV16, 18, or 45 infection (292 HPV persisters) were also included.
The researchers found that relative to either control group, patients with AIS/ADC and with CIN3/SCC had higher methylation percentages at each individual CpG site in exfoliated cervicovaginal cells. For AIS/ADC, the methylation score had a sensitivity and specificity of 74 and 89 percent, respectively. Using HPV clearers as controls, the multivariate odds ratio between the fourth and first quartile of the methylation score for AIS/ADC was 49.01; similar albeit weaker, associations were seen for CIN3/SCC.
"If confirmed, our findings suggest that HPV16/18/45-positive women with a high Methylation Score may warrant enhanced screening with careful histologic evaluation of the cervical transition zone," the authors write.
Two authors disclosed ties to the pharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted September 2023
Read this next
Implantable Continuous Flow Device Feasible for Small Children With Severe Systolic Heart Failure
FRIDAY, May 10, 2024 -- The Jarvik 2015 left ventricular assist device (LVAD) seems promising as an implantable continuous flow device for small children with severe systolic...
Clinical Practice Guideline Developed for Age-Related Hearing Loss
FRIDAY, May 10, 2024 -- In a clinical practice guideline issued by the American Academy of Otolaryngology-Head and Neck Surgery Foundation and published online April 30 in...
Large Language Models Fall Short in Breast Imaging Classification
FRIDAY, May 10, 2024 -- Large language models (LLMs) appear to fall short in classification of breast imaging, which can have a negative impact on clinical management, according...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.