Machine Learning Model Can Predict Mortality After Hip Fracture
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
FRIDAY, Sept. 22, 2023 -- A machine learning model based on high-ranking biomarkers can predict mortality in patients with hip fracture, according to a study published online Sept. 20 in the Journal of Orthopedic Research.
George Asrian, M.D., Ph.D., from the University of Pennsylvania in Philadelphia, and colleagues examined whether a machine learning model trained on basic blood and lab test data as well as basic demographic data can predict mortality following a hip fracture. Key variables most associated with one-, five-, and 10-year mortality were identified, and their clinical significance was investigated. Data were included for 3,751 hip fracture patients.
The researchers found that the one-year mortality rate was 21 percent for all patients studied and 29 percent for those aged 80 years and older. Ten different machine learning classification models were assessed; LightGBM had the strongest prediction performance for one-year mortality, with accuracy of 91 percent, an area under the receiver operating characteristic curve of 0.79, and sensitivity and specificity of 0.34 and 0.98, respectively, on the test set. For the one-year model, the strongest-weighted features included age, glucose, red blood cell distribution width, mean corpuscular hemoglobin concentration, white blood cells, urea nitrogen, prothrombin time, platelet count, calcium levels, and partial thromboplastin time. The top 10 features of the LightGBM five- and 10-year prediction models included most of these features.
"LightGBM is a robust and powerful tool for predicting mortality across short and long timeframes, allowing for simple analysis of the most important input variables," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted September 2023
Read this next
Survival Possible for Some With TBI for Whom Treatment Was Withdrawn
MONDAY, May 13, 2024 -- A substantial proportion of patients with traumatic brain injury (TBI) who undergo withdrawal of life-sustaining treatment (WLST) could have survived and...
Study Identifies Factors Associated With Hydroxychloroquine Retinopathy
MONDAY, May 13, 2024 -- Factors associated with an increased risk for hydroxychloroquine retinopathy have been identified and include female sex, older age, and chronic kidney...
Adding Cardiovascular Biomarkers to Established Risk Factors Increases Risk Prediction
MONDAY, May 13, 2024 -- The addition of cardiovascular biomarkers to established risk factors leads to a small improvement in risk prediction of cardiovascular disease, according...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.