Skip to main content

Lower SBP Targets After Endovascular Therapy Do Not Meet Futility Criteria

Medically reviewed by Drugs.com.

By Elana Gotkine HealthDay Reporter

WEDNESDAY, Sept. 20, 2023 -- For patients with acute ischemic stroke undergoing endovascular therapy, lower systolic blood pressure (SBP) targets do not meet prespecified criteria for futility, according to a study published in the Sept. 5 issue of the Journal of the American Medical Association.

Eva A. Mistry, M.B.B.S., from the University of Cincinnati, and colleagues examined the futility of lower SBP targets versus a higher target (<140 or <160 mm Hg versus ≤180 mm Hg) after endovascular therapy in a randomized, phase 2 trial involving 120 patients with acute ischemic stroke who had undergone successful endovascular therapy during January 2020 to March 2022.

The researchers found that the mean follow-up infarct volume was 32.4, 50.7, and 46.4 mL for the <140, <160, and ≤180 mm Hg groups, respectively. The mean utility-weight modified Rankin Scale (mRS) score was 0.51, 0.47, and 0.58 for the <140, <160, and ≤180 mm Hg groups, respectively. For each mm Hg decrease in the SBP target, the slope of follow-up infarct volume was −0.29 and the slope of the utility-weighted mRS score was −0.0019. The predicted probability of success for a future trial was 25 and 14 percent for the <140 and <160 mm Hg groups, respectively, compared with the ≤180 mm Hg group.

"Although the study did not find significant evidence of an unequivocal harm of lower blood pressure targets in this population in terms of worsening size of stroke or increasing disability, the trends indicated that there may only be marginal benefit of lowering postendovascular treatment blood pressure on patients' long-term disability," Mistry said in a statement.

Several authors disclosed ties to the biopharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2024 HealthDay. All rights reserved.

Posted September 2023

Read this next

Blood Pressure Down With Self-Monitoring of BP, Self-Titration of Medications

FRIDAY, May 10, 2024 -- Blood pressure (BP) self-monitoring, together with self-titration of antihypertensive medications, is associated with a reduction in BP, according to a...

Thrombectomy Linked to Better Outcomes for Acute Stroke, Large Infarct

THURSDAY, May 9, 2024 -- For patients with acute stroke and a large infarct, thrombectomy plus medical care results in better functional outcomes and lower mortality, according to...

Novel Genetic Loci ID'd for Hypertension in European Ancestry

TUESDAY, May 7, 2024 -- A total of 113 novel genetic loci have been identified in the largest single-stage common variant genome-wide association study of blood pressure (BP)...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.