Low-Dose Direct Oral Anticoagulants Tied to More Bleeding Episodes
By Lori Solomon HealthDay Reporter
WEDNESDAY, June 19, 2024 -- Patients with atrial fibrillation (AF) on low doses of direct oral anticoagulants (DOACs) have more bleeding episodes than those on standard doses, according to a study published online June 6 in Blood Advances.
Gualtiero Palareti, M.D., from Fondazione Arianna Anticoagulazione in Bologna, Italy, and colleagues collected venous blood at 15 to 30 days after DOAC initiation in patients with AF who were then followed for one year to examine the occurrence of major and clinically relevant nonmajor bleeding. The analysis included 1,657 patients treated with standard DOACs and 700 with low-dose DOACs.
The researchers found that 50 bleeding events were recorded during 1,606 years of follow-up (3.11 percent per patient-year). In the highest C-trough standardized values activity class, 15 bleeding events (4.97 percent per patient-year) occurred (>0.50) versus 35 events (2.69 percent per patient-year) in those with values in the two lower classes. Increased bleeding risk in the first three months of treatment was seen with increasing DOAC levels and low-dose DOAC use. Among patients receiving low doses, 19 percent had standardized activity values in the highest class. For low-dose DOACs, more bleeding occurred (4.3 percent per patient-year) compared with the standard dose (2.2 percent per patient-year).
"Early measurement of DOAC levels in AF patients identified many subjects with high activity levels despite the low doses use and had more bleeding risk during the first three months of treatment," the authors write.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted June 2024
Read this next
Racial Differences Seen in Financial Hardship Among Older Cancer Survivors
MONDAY, July 1, 2024 -- Income and area-level disadvantage are the largest contributors to racial differences in financial hardship among older U.S. adults with cancer, according...
Housing Insecurity Linked to Poorer Teen Health Outcomes
MONDAY, July 1, 2024 -- There is an association for housing insecurity starting in infancy and poorer adolescent outcomes, according to a study published online July 1 in...
Sound Stimulation Aids Saccular Dysfunction With Meniere Disease
MONDAY, July 1, 2024 -- Sound stimulation of 75 dB at a frequency of 100 Hz leads to improvement in cervical vestibular-evoked myogenic potential (cVEMP) amplitude...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.