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Higher BMI Variability Linked to Adverse Cardiovascular Disease Events

Medically reviewed by Carmen Pope, BPharm. Last updated on March 25, 2024.

By Elana Gotkine HealthDay Reporter

MONDAY, March 25, 2024 -- Higher body mass index (BMI) variability is associated with adverse cardiovascular disease (CVD) events, according to a study published online March 21 in JAMA Network Open.

Zakaria Almuwaqqat, M.D., M.P.H., from the Veterans Affairs Atlanta Healthcare System in Decatur, Georgia, and colleagues examined the association between BMI variability and incident CVD events in two cohorts (the Million Veteran Program [MVP] and the U.K. Biobank [UKB]).

There were 4,811 composite CVD events recorded from 2011 to 2018 among the 92,363 U.S. veterans in the MVP cohort. The researchers found that the coefficient of variation of BMI was associated with an increased risk for composite CVD across all groups (hazard ratio, 1.16). Among subgroups and after adjustment for the polygenic score of BMI, these associations were unchanged. There were 6,934 composite CVD events among the 65,047 individuals in the UKB cohort. The risk for cardiovascular death increased significantly for each one-standard deviation increase in BMI variability in the UKB cohort (hazard ratio, 1.08).

"These findings suggest that greater BMI changes could be related to a high-risk phenotype for CVD, with unique metabolic and genetic mechanisms," the authors write. "Future studies should focus on identifying molecular risk pathways mediating this association."

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

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Posted March 2024

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