Chemoradiation With SABR Boost Safe, Effective for Advanced Lung Cancer
By Elana Gotkine HealthDay Reporter
TUESDAY, Jan. 16, 2024 -- Chemoradiation with an adaptive stereotactic ablative radiotherapy (SABR) boost is safe and effective for patients with locally advanced, unresectable non–small cell lung cancer (NSCLC), according to a study published online Jan. 11 in JAMA Oncology.
Trudy C. Wu, M.D., from the University of California in Los Angeles, and colleagues examined the maximum tolerated dose (MTD) and use of hypofractionated concurrent chemoradiation with an adaptive SABR boost among patients with clinical stage II or III NSCLC. All patients first received 4 Gy x 10 fractions followed by an adaptive SABR boost consisting of an additional 25 Gy (low), 30 Gy (intermediate), or 35 Gy (high) with concurrent weekly carboplatin/paclitaxel. Data were evaluated from 28 patients (24 with stage III disease) enrolled across the low-, intermediate-, and high-dose cohorts (10, nine, and nine, respectively).
The researchers found that the protocol-specified MTD was not exceeded in the study. Nonhematologic acute and late grade 3 or higher effects had incidences of 11 and 7 percent, respectively. In the intermediate-dose boost cohort, there were no grade 3 toxic effects. In the high-dose cohort, there were two deaths. For the low-, intermediate-, and high-dose cohorts, two-year local control was 74.1, 85.7, and 100.0 percent, respectively, and two-year overall survival was 30.0, 76.2, and 55.6 percent, respectively.
"The present findings suggest that increasing the BED [biologic effective dose] through hypofractionation may enhance LC [local control], but this approach is limited by grade 5 toxic effects beyond a certain BED, which was 70 Gy in 15 fractions in this study," the authors write.
Several authors disclosed ties to the pharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted January 2024
Read this next
Alecensa Approved as First and Only ALK Inhibitor for Non-Small Cell Lung Cancer
MONDAY, April 22, 2024 -- The U.S. Food and Drug Administration has approved Alecensa (alectinib) as adjuvant treatment following tumor resection in patients with anaplastic...
Tumor-Infiltrating Lymphocyte Abundance Prognostic in Early-Stage TNBC
THURSDAY, April 18, 2024 -- For patients with early-stage triple-negative breast cancer (TNBC) who undergo surgery without chemotherapy, tumor-infiltrating lymphocyte (TIL)...
Adjuvant Alectinib Improves Disease-Free Survival in Lung Cancer
FRIDAY, April 12, 2024 -- Adjuvant alectinib improves disease-free survival compared with platinum-based chemotherapy among patients with resected ALK-positive non-small cell lung...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.