Skip to main content

CD7 Expression Tied to Poorer Outcomes With Newly Diagnosed Leukemia

Medically reviewed by Carmen Pope, BPharm. Last updated on May 3, 2024.

By Lori Solomon HealthDay Reporter

FRIDAY, May 3, 2024 -- CD7 expression is associated with poorer outcomes in patients with newly diagnosed acute myeloid leukemia (AML), according to a study published online April 11 in the British Journal of Haematology.

Wei-Ying Jen, B.M., B.Ch., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues collected flow cytometry data on 901 patients with AML and examined aberrant CD7 expression on leukemic blasts.

The researchers found that 29.2 percent had blasts positive for CD7. Adverse risk was more likely (64.6 versus 55.6 percent) and favorable risk was less likely (15.2 versus 24.1 percent) with CD7-positive AML by European LeukemiaNet 2022 criteria. Additionally, overall survival was inferior (11.9 versus 19.0 months). Moderate instability over time was seen, with 30.4 percent losing and 19.0 percent gaining CD7 at relapse.

"In summary, we report on a large population of AML with attention to CD7 expression, genomic profiles and patient outcomes," the authors write. "The retrospective nature of the study and the number of associated cytomolecular characteristics require a large sample size, and the identification of any associations will require further evaluation and confirmation in independent datasets."

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Posted May 2024

Read this next

Disparities Identified in Leukemia Incidence, Mortality in Florida

TUESDAY, March 25, 2025 -- There are racial and geographic disparities in the incidence of and mortality from adult leukemia in Florida, where the incidence of leukemia is the...

Protracted Radiation Exposure Linked to Hematologic Cancer Mortality

THURSDAY, Oct. 24, 2024 -- Protracted low-dose exposure to ionizing radiation among radiation-monitored workers is associated with mortality due to some hematologic malignancies...

Overall Survival Improving for Umbilical Cord Blood Transplant

MONDAY, Oct. 7, 2024 -- For umbilical cord blood transplant (UCBT), overall survival has improved over time, according to a study published in the October issue of Transplantation...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.