Atropine 0.01 Percent Eye Drops Do Not Slow Myopia Progression
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
MONDAY, July 17, 2023 -- For children aged 5 to 12 years with low-to-moderate bilateral myopia, atropine 0.01 percent eye drops do not slow myopia progression over two years of treatment, according to a study published online July 13 in JAMA Ophthalmology.
Michael X. Repka, M.D., from the Wilmer Eye Institute in Baltimore, and colleagues conducted a randomized, placebo-controlled trial involving children aged 5 to 12 years with low-to-moderate bilateral myopia (−1.00 to −6.00 diopters [D] spherical equivalent refractive error [SER]). A total of 187 children were included in the study: 125 received atropine and 62 received placebo. Children received treatment for 24 months, followed by six months of observation.
The researchers found that the adjusted mean change in SER from baseline was −0.82 and −0.80 in the atropine and placebo groups, respectively, at the 24-month primary outcome visit (difference, −0.02; 95 percent confidence interval, −0.19 to +0.15 D). At 30 months, the adjusted difference in mean SER change from baseline was −0.04 D (−0.25 to +0.17 D). From baseline to 24 months, the adjusted mean changes in axial length were 0.44 and 0.45 in the atropine and placebo groups, respectively (difference, −0.002 mm [−0.106 to 0.102 mm]). From baseline to 30 months, the adjusted difference in mean axial elongation was +0.009 mm (−0.115 to 0.134 mm).
"Overall, clinical trials investigating atropine, 0.01 percent, for myopia control, including the well-done study by Repka et al., indicate that stronger concentrations of atropine should be considered for first-line treatment of myopia progression," write the authors of an accompanying editorial.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted July 2023
Read this next
Neighborhood Inequity Tied to More People Living With Vision Difficulty, Blindness
TUESDAY, May 14, 2024 -- Residential measures of inequity are associated with a greater number of individuals living with vision difficulty and blindness (VDB), according to a...
AI Shows Good Clinical Knowledge, Reasoning for Eye Issues
FRIDAY, April 26, 2024 -- Large language models (LLMs) are approaching expert-level knowledge and reasoning skills in ophthalmology, according to a study published online April 17...
Childhood Amblyopia Linked to Cardiometabolic Dysfunction in Adults
WEDNESDAY, March 20, 2024 -- Adults who had childhood amblyopia have greater cardiometabolic dysfunction, according to a study published online March 7 in...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.