ASCO: Osimertinib Improves Progression-Free Survival in EGFR-Mutated Lung Cancer
By Elana Gotkine HealthDay Reporter
WEDNESDAY, June 5, 2024 -- For patients with unresectable stage III EGFR-mutated non-small cell lung cancer (NSCLC), treatment with osimertinib results in significantly longer progression-free survival, according to a study published online June 2 in the New England Journal of Medicine to coincide with the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.
Shun Lu, M.D., from Shanghai Chest Hospital, and colleagues conducted a double-blind trial involving patients with unresectable EGFR-mutated stage III NSCLC without progression during or after chemoradiotherapy. Participants were randomly assigned to receive osimertinib or placebo (143 and 73 patients, respectively) until disease progression or discontinuation of the regimen.
The researchers found that compared with placebo, osimertinib resulted in a significant progression-free survival benefit, with median progression-free survival of 39.1 and 5.6 months with osimertinib and placebo, respectively (hazard ratio for disease progression or death, 0.16; 95 percent confidence interval, 0.10 to 0.24; P < 0.001). At 12 months, the percentage of patients who were alive and progression-free was 74 and 22 percent with osimertinib and placebo, respectively. Based on interim survival data, 36-month overall survival was 84 and 74 percent with osimertinib and placebo, respectively (hazard ratio for death, 0.81; 95 percent confidence interval, 0.42 to 1.56; P = 0.53). The incidence of adverse events of grade 3 or higher was 35 and 12 percent in the osimertinib and placebo groups, respectively.
"Treatment with osimertinib after chemoradiotherapy resulted in significantly longer progression-free survival than placebo among patients with unresectable stage III EGFR-mutated NSCLC," the authors write.
Several authors disclosed ties to pharmaceutical companies, including AstraZeneca, which manufactures osimertinib and funded the study.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted June 2024
Read this next
Durable Disease Control Possible After Stopping Immune Checkpoint Inhibitors in NSCLC
TUESDAY, April 22, 2025 -- Prolonged disease control can be maintained for patients with advanced non-small cell lung cancer (NSCLC) who discontinue immune checkpoint inhibitors...
More Than 3.8 Million U.S. Lung Cancer Deaths Averted During 1970 to 2022
TUESDAY, April 1, 2025 -- More than 3.8 million U.S. lung cancer deaths were averted during 1970 to 2022, and more than 76 million person-years of life were gained, according to a...
Lung Cancer Screening Rates Increased After 2021 Update to USPSTF Guidelines
MONDAY, March 31, 2025 -- Increased lung cancer screening uptake was seen after the 2021 update to the U.S. Preventive Services Task Force (USPSTF) guidelines, which expanded...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.