Antibody-Positive Males Face Higher Risk for Type 1 Diabetes Progression
By Lori Solomon HealthDay Reporter
TUESDAY, Aug. 6, 2024 -- The risk for progression to type 1 diabetes (T1D) is significantly higher in antibody-positive males compared with females, with age differences in risk trajectories, according to a study scheduled to be presented at the annual meeting of the European Association for the Study of Diabetes, being held from Sept. 9 to 13 in Madrid.
Erin L. Templeman, from the University of Exeter in the United Kingdom, and colleagues assessed the risk and rate of progression for individuals at risk for T1D participating in the TrialNet Natural History study. The analysis included 235,765 relatives of people with T1D screened for autoantibody (AB) positivity.
The researchers found that the proportion of individuals who screened positive for ABs was higher in males (females: 0.05; males: 0.054). Of those screening positive, males were more likely to screen positive for multiple ABs (females: 0.018; males: 0.026). Additionally, the absolute five-year risk for progression to T1D was significantly higher among males who were single AB-positive (14 percent for females versus 21 percent for males). A similar risk was seen for males and females presenting with stage 1 (females: 38 percent; males: 38 percent) or stage 2 (females: 57 percent; males: 59 percent). For females, a large decrease in five-year T1D risk was seen when screened and autoantibody-positive before age 10 years versus after age 10 years. However, there was a steady decline in five-year T1D risk among males as age at screening increased.
"The change in risk at around the age of 10 raises the hypothesis that puberty-related hormones may play a role," the authors said in a news release.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.
Posted August 2024
Read this next
CRC as First of Multiple Primary Malignancies Tied to Better Outcomes Than CRC as Only Malignancy
THURSDAY, June 26, 2025 -- Compared with colorectal cancer (CRC) presenting as an isolated primary or second primary malignancy, CRC presenting as the first of multiple primary...
Two-Hour Observation Probably Safe for Most Children With Anaphylaxis
THURSDAY, June 26, 2025 -- For most children who present to an emergency department with an acute allergic reaction requiring epinephrine, a two-hour observation period is...
CT Perfusion and CT Angiography Not Useful as Standalone Tests for Establishing Death by Neurologic Criteria
THURDAY, June 26, 2025 -- Neither computed tomography (CT) perfusion nor CT angiography meet the prespecified validation threshold as an ancillary test for death by neurologic...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.