Allogeneic Hematopoietic Cell Transplant Outcomes Improved From 2005 to 2019
Medically reviewed by Drugs.com.
By Lori Solomon HealthDay Reporter
FRIDAY, June 16, 2023 -- Outcomes of allogeneic hematopoietic cell transplantation (allo-HCT) in patients with acute myeloid leukemia (AML) and second complete remission (CR2) have significantly improved over time, according to a study published online June 2 in Cancer.
Rama Al Hamed, M.D., from Sorbonne University in Paris, and colleagues investigated changes in patient- and transplant-related characteristics and posttransplant outcomes over time among 3,955 adult patients with AML receiving allo-HCT.
The researchers found that 725 patients were transplanted between 2005 and 2009, 1,600 between 2010 and 2014, and 1,630 between 2015 and 2019. Across time, there was a significant increase observed in patient age (from 48.7 to 53.5 years), use of a haploidentical donor (from 4.6 to 26.4 percent), and use of posttransplant cyclophosphamide (from 0.4 to 29 percent). Over the same time period, there was a significant decrease observed in total body irradiation and in vivo T-cell depletion. Transplants performed more recently had better outcomes, with leukemia-free survival (hazard ratio [HR], 0.79) and overall survival (HR, 0.73) increasing over time and nonrelapse mortality decreasing over time (HR, 0.64). Graft-versus-host disease (GVHD) rates also improved (acute GVHD II-IV: HR, 0.78; GVHD-free, relapse-free survival: HR, 0.69).
“The best outcomes were with the use of a matched unrelated donor, given better leukemia-free survival, overall survival, and nonrelapse mortality, which helps to highlight that in the absence of a matched sibling donor, a matched unrelated donor could be a viable option for this patient population,” the authors write.
Several authors disclosed ties to the pharmaceutical industry.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted June 2023
Read this next
Lower Prevalence of Employment Seen for Survivors of Childhood Cancer
FRIDAY, May 10, 2024 -- Adult survivors of childhood cancer have declines in employment and increases in health-related unemployment compared with the general population...
Persistent Sociodemographic Differences Seen in Use of AutoHCT for Multiple Myeloma
WEDNESDAY, May 8, 2024 -- Sociodemographic differences persist in utilization of autologous hematopoietic cell transplantation (autoHCT) for multiple myeloma, according to a study...
Hematopoietic Cell Transplantation Use Has Increased for All Racial Groups
MONDAY, May 6, 2024 -- Hematopoietic cell transplantation (HCT) use has increased among all racial/ethnic groups and has increased faster among non-Hispanic African Americans...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.