AACR: Novel Personalized Vaccine Feasible for Head and Neck Cancer
By Elana Gotkine HealthDay Reporter
TUESDAY, April 9, 2024 -- The novel viral-based personalized cancer vaccine, TG4050, which encodes up to 30 patient- and tumor-specific sequences is feasible and safe for patients with resected head and neck squamous cell carcinoma, according to a study presented at the annual meeting of the American Association for Cancer Research, held from April 5 to 10 in San Diego.
Ana I. Lalanne, Ph.D., from the Institut Curie in Paris, and colleagues randomly assigned eligible patients with completely resected stage III or IV human papillomavirus-negative squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx to receive TG4050 immediately (arm A; 17 patients) or upon relapse (arm B; 16 patients) after completion of standard-of-care adjuvant radio-chemotherapy.
The researchers found that TG4050 adverse events were mild to moderate, and most of them were injection site reactions. No relapse occurred in arm A, and three patients relapsed in arm B after 6.2, 8.8, and 18.5 months, after a median follow-up of 16.2 months. T-cell responses were de novo or amplification of preexisting responses (82 and 18 percent, respectively). There was a median of six vaccine responses observed. An effector memory phenotype was indicated in cytometric characterization of vaccine-specific T-cells. In five patients, T-cell receptor sequencing of blood T-cells evidenced expansion of tumor-infiltrating lymphocyte clonotypes. In the blood of two patients, the most expanded vaccine-specific CD8 T-cells represented oligoclonal expansions expressing an effector phenotype.
"Our findings indicate that TG4050 is safe and promotes an immune response against several neoantigens in most patients," coauthor Olivier Lantz, M.D., Ph.D., also from the Institute Curie, said in a statement.
Several authors disclosed ties to pharmaceutical companies, including Transgene, which sponsored the study and jointly funded it with NEC.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted April 2024
Read this next
Text Messages + Financial Incentives Boost Weight Loss at 12 Months
WEDNESDAY, May 15, 2024 -- Among men with obesity, an intervention with text messaging plus financial incentive significantly improves weight loss compared with a control group...
AACR Delivers Report on Disparities in Cancer Progress
WEDNESDAY, May 15, 2024 -- In its biennial Cancer Disparities Progress Report published today, the American Association for Cancer Research presents the latest statistics on...
High Telehealth Use Tied to Increased Health Care Utilization, Cost
TUESDAY, May 14, 2024 -- Higher telehealth use in a hospital service area is tied to increased health care utilization and cost, according to a study published online May 13...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.