Generic Name: nusinersen (injection) (NUE si NER sen)
Brand Name: Spinraza
Medically reviewed on April 28, 2017.
What is nusinersen?
Nusinersen works by helping the body produce a protein essential to the function of nerves that control muscle movement. This protein is lacking in people with an inherited disorder called spinal muscular atrophy caused by a mutation in a specific gene.
Nusinersen is used to treat spinal muscular atrophy in adults, children, and infants.
Nusinersen may also be used for purposes not listed in this medication guide.
Call your doctor for instructions if you miss an appointment for your nusinersen injection.
Before taking this medicine
You should not be treated with nusinersen if you are allergic to it.
To make sure nusinersen is safe for you, tell your doctor if you have:
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether nusinersen passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
How is nusinersen given?
Your doctor will perform blood and urine tests to make sure you do not have conditions that would prevent you from safely receiving this medicine.
Nusinersen is injected directly into the fluid that surrounds the brain and spinal cord (cerebrospinal fluid). A healthcare provider will give you this injection.
The nusinersen injection takes about 1 to 3 minutes to complete. You may be given a sedative to help you relax and keep you comfortable during the injection.
Nusinersen is usually given in a series of 4 "loading dose" injections, followed by "maintenance" injections.
The first 3 loading doses are usually given 2 weeks apart, followed by a 4th loading dose given 1 month later. Maintenance doses are then given once every 4 months.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your nusinersen injection. Your dosing schedule may need to be adjusted to allow for enough time between doses.
What happens if I overdose?
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving nusinersen?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Nusinersen side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
chest pain, shortness of breath;
a red skin rash; or
kidney problems--foamy urine; red or brown colored urine; swelling in your face, stomach, hands, or feet.
Nusinersen may affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Nusinersen dosing information
Usual Adult Dose for Spinal Muscular Atrophy:
-Initial dose: 12 mg intrathecally per administration; initiate therapy with 4 loading doses; administer the first 3 loading doses at 14-day intervals; administer the 4th loading dose 30 days after the 3rd dose
-Maintenance dose: 12 mg intrathecally once every 4 months
-If a loading dose is delayed or missed, administer it as soon as possible, with at least 14-days between doses and continue dosing as prescribed.
-If a maintenance dose is delayed or missed, administer it as soon as possible and continue dosing every 4 months.
Use: For the treatment of spinal muscular atrophy (SMA)
Usual Pediatric Dose for Spinal Muscular Atrophy:
17 years and older: Use adult dosing
What other drugs will affect nusinersen?
Other drugs may interact with nusinersen, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 1.03.
More about nusinersen
- Nusinersen Side Effects
- During Pregnancy
- Dosage Information
- Support Group
- En Español
- 0 Reviews – Add your own review/rating
- Drug class: miscellaneous uncategorized agents
Other brands: Spinraza