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Nusinersen Dosage

Applies to the following strengths: 12 mg/5 mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Spinal Muscular Atrophy

-Initial dose: 12 mg intrathecally per administration; initiate therapy with 4 loading doses; administer the first 3 loading doses at 14-day intervals; administer the 4th loading dose 30 days after the 3rd dose
-Maintenance dose: 12 mg intrathecally once every 4 months

Comments:
-If a loading dose is delayed or missed, administer it as soon as possible, with at least 14-days between doses and continue dosing as prescribed.
-If a maintenance dose is delayed or missed, administer it as soon as possible and continue dosing every 4 months.

Use: For the treatment of spinal muscular atrophy (SMA)

Usual Pediatric Dose for Spinal Muscular Atrophy

17 years and older: Use adult dosing

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 17 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug should be administered by, or under the direction of, a healthcare professional experienced in performing lumbar punctures.
-Consider sedation as indicated by the clinical condition of the patient.
-Consider ultrasound or other imaging techniques to guide intrathecal administration, particularly in younger patients.
-Prior to administration, remove 5 mL of cerebrospinal fluid (CSF).
-Administer as an intrathecal bolus injection over 1 to 3 minutes using a spinal anesthesia needle.
-Do not administer in areas of the skin where there are signs of infection or inflammation.

Storage requirements:
-Store in the original carton in the refrigerator until time of use.

Reconstitution/preparation techniques:
-Allow vial to warm to room temperature (25C) prior to administration; do not use external heat sources.
-Inspect vial for particulate matter and discoloration prior to administration; do not administer if visible particulates are observed or if the liquid in the vial is discolored.
-Withdraw 12 mg from the single-dose vial into a syringe and discard unused contents of vial.
-Administer within 4 hours of removal from vial.

IV compatibility:
-The manufacturer product information should be consulted.

Monitoring:
-Platelet count
-Prothrombin time; activated partial thromboplastin time
-Quantitative spot urine protein testing

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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