Generic Name: corticorelin ovine triflutate (KOR ti koe REL in OH vine TRYE floo ate)
Brand Name: Acthrel
Medically reviewed on Apr 17, 2018
What is Acthrel?
Acthrel is a man-made form of a hormone that occurs naturally in the body.
Acthrel is used as part of a medical test in people with Cushing's syndrome. Cushing syndrome is caused by high levels of cortisol (a steroid hormone produced by the adrenal gland).
Acthrel is also used to help your doctor determine why your body is producing too much of its own cortisol.
Acthrel may also be used for purposes not listed in this medication guide.
Before you receive Acthrel, tell your doctor about all your medical conditions and allergies.
Before taking this medicine
Before you receive this medicine, tell your doctor about all your medical conditions and allergies.
FDA pregnancy category C. It is not known whether Acthrel will harm an unborn baby. Tell your doctor if you are pregnant.
It is not known whether corticorelin ovine triflutate passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How is Acthrel given?
Acthrel is injected into a vein through an IV. A healthcare provider will give you this injection in a hospital or clinic setting.
Acthrel is usually given as a single injection for a corticorelin test. Your caregivers will need to draw at least 5 blood samples from you before and after you receive the medicine.
In most cases, the blood is tested 15 minutes before and then right before you receive the injection. These tests will give your doctor two "baseline" measurements.
After you receive Acthrel, your blood will be drawn again at 15 minutes, 30 minutes, and 60 minutes after the injection. This will help your doctor determine more about your condition.
The timing of your blood tests before and after the injection is important in assuring the most accurate results from a corticorelin test. Plan to stay in the care of your healthcare providers for at least 1 hour after your injection.
What happens if I miss a dose?
Since Acthrel is used as a single dose, it does not have a daily dosing schedule.
What happens if I overdose?
Since Acthrel is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid after receiving Acthrel?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Acthrel side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your caregiver right away if you have:
chest pain or pressure, fast heart rate;
trouble breathing, feeling like you can't get enough air;
severe redness or warmth in your face; or
a light-headed feeling, like you might pass out.
Common side effects may include:
flushing (warmth, redness, or tingly feeling) in your face, neck, or chest.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Acthrel?
Other drugs may interact with corticorelin ovine triflutate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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