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How long does it take Tecfidera to start working?

Medically reviewed by Carmen Fookes, BPharm. Last updated on Aug 27, 2020.

Official Answer

by Drugs.com

Tecfidera starts to work within 24 weeks; however, it may take up to two years for the full effects to be seen.

Studies report that after 2 years, people taking Tecfidera were:

  • 44% to 53% less likely to relapse every year when taking Tecfidera compared with those taking placebo
  • 21% to 28% less likely to have a progression of their disability while taking Tecfidera compared to those assigned to placebo
  • 74% to 90% less likely to develop new or newly enlarging T2 lesions or have Gd lesions.

It took 24 weeks for a difference to be noted between Tecfidera 240mg twice daily and placebo for the time to 12 week confirmed progression of disability; 6% of people taking Tecfidera had a confirmed progression of disability vs 8% taking placebo after 24 weeks. After 2 years 16.4% taking Tecfidera had disability progression compared with 27.1% assigned to placebo which corresponded to a risk reduction of 38%. Another study reported a 21% risk reduction in disability progression.

Disability progression was defined as at least a 1 point increase on the EDSS (Expanded Disability Status Scale) from the baseline EDSS of >1, or a 1.5 increase on the EDSS from a baseline EDSS of 0 which was confirmed for at least 12 weeks.

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