Generic name: tebentafusp-tebn
Dosage form: injection
Drug class: Bispecific T-cell engagers (BiTE)

Medically reviewed by Judith Stewart, BPharm. Last updated on Jan 22, 2024.

What is Kimmtrak?

Kimmtrak is a prescription medicine used to treat HLA-A*02:01-positive adults with uveal melanoma that cannot be removed by surgery or has spread.

Your healthcare provider will test you for a presence of HLA-A*02:01 gene to make sure Kimmtrak is right for you. It is not known if this medicine is safe and effective in children.

Important information

Kimmtrak can cause serious side effects that can be severe or, life threatening, and usually happens within the first three infusions. These side effects include:

• Cytokine Release Syndrome (CRS). Tell your healthcare provider right away if you get any of the following symptoms:
  • fever
  • tiredness or weakness
  • vomiting
  • chills
  • nausea
  • low blood pressure
  • dizziness and light headedness
  • headache
  • wheezing and trouble breathing
  • rash

Your healthcare provider will check for these problems during treatment. Your healthcare provider may temporarily stop or completely stop your treatment if you have severe side effects.

See Kimmtrak side effects for more information about side effects.

Before you receive Kimmtrak

Before you receive Kimmtrak, tell your healthcare provider about all of your medical conditions, including if you:

• are pregnant or plan to become pregnant. Kimmtrak may harm your unborn baby. Tell your healthcare provider if you become pregnant during treatment.

For females who are able to become pregnant:

• Your healthcare provider should do a pregnancy test before you start treatment.
• Use an effective form of birth control during treatment, and for at least 1 week after the last dose.
• are breastfeeding or plan to breastfeed. It is not known if Kimmtrak passes into your breast milk. Do not breastfeed during the treatment, and for at least 1 week after the last dose.

What other drugs will affect Kimmtrak?

Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive Kimmtrak?

• Kimmtrak will be given to you by intravenous (IV) infusion into your vein for 15 to 20 minutes.
• Kimmtrak is usually given every week.
• Your healthcare provider will decide how many treatments you need.
• Your healthcare provider will keep you under observation for at least 16 hours following the first three treatments and for at least 30 minutes after future treatments.
• Your healthcare provider may delay your treatment if you have certain side effects.
• Your healthcare provider may do blood tests regularly during treatment.

Dosing information

Usual Adult Dose for Uveal Melanoma

- 20 mcg intravenously on Day 1, 30 mcg intravenously on Day 8, 68 mcg intravenously on Day 15, and 68 mcg intravenously once every week thereafter. 

- Use: treatment of HLA-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma.

Kimmtrak side effects

Kimmtrak can cause serious side effects, including:

• See Important information.
• Skin reactions. Kimmtrak may cause skin reactions that require treatment. Tell your healthcare provider if you get symptoms of skin reactions, such as rash, itching, or skin swelling, that are severe and do not go away.
• Abnormal liver blood tests. Your healthcare provider will do blood tests to check your liver before you start Kimmtrak and during treatment. Tell your healthcare provider if you get symptoms of liver problems such as right-sided abdominal pain or yellowing of the skin or eyes.

The most common side effects include:

• cytokine release syndrome (CRS)
• rash
• fever
• itching
• tiredness
• nausea
• chills
• stomach pain
• swelling
• low blood pressure (symptoms may include dizziness or light headedness)
• dry skin
• headache
• vomiting
• abnormal liver blood tests

These are not all the possible side effects. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA1088.

General information about safe and effective use of Kimmtrak.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information Leaflet. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider for more information that is written for healthcare professionals.

What are the ingredients in Kimmtrak?

Active ingredient: tebentafusp
Inactive ingredients: citric acid monohydrate, di-sodium hydrogen phosphate, mannitol, polysorbate 20, trehalose, and Water for injection.

Kimmtrak Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for Kimmtrak.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer