Tacrolimus (International)
In the US, Tacrolimus (tacrolimus systemic) is a member of the drug class calcineurin inhibitors and is used to treat Crohn's Disease, Graft-versus-host disease, Nephrotic Syndrome, Organ Transplant - Rejection Prophylaxis and Organ Transplant - Rejection Reversal.
US matches:
- Tacrolimus oral and injection
- Tacrolimus topical
- Tacrolimus (Intravenous)
- Tacrolimus (Oral)
- Tacrolimus (Topical)
- Tacrolimus
- Tacrolimus 0.03% Ointment
- Tacrolimus 0.1% Ointment
- Tacrolimus Capsules
- Tacrolimus Extended-Release Capsules
- Tacrolimus Extended-Release Tablets
- Tacrolimus Granules for Suspension
- Tacrolimus Injection
- Tacrolimus ER Capsules
- Tacrolimus Ointment
Scheme
Rec.INN
ATC (Anatomical Therapeutic Chemical Classification)
D11AH01,L04AA05,L04AD02
CAS registry number (Chemical Abstracts Service)
0104987-11-3
Chemical Formula
C44-H69-N-O12
Molecular Weight
804
Therapeutic Category
Immunosuppressant
Chemical Name
Immunosuppreβant derived from Streptomyces tsukubaensis
Foreign Names
- Tacrolimusum (Latin)
- Tacrolimus (German)
- Tacrolimus (French)
- Tacrolimus (Spanish)
Generic Names
- Tacrolimus (OS: USAN, BAN)
- Tacrolimus (PH: USP 41)
- Tacrolimus Hydrate (OS: JAN)
- FK 506 (Fujisawa) (IS)
- FR 900506 (IS)
- L 683590 (IS)
- Tacrolimus Hydrate (PH: JP XVII)
- Tacrolimus Monohydrate (PH: BP 2018, Ph. Eur. 9.3)
Brand Names
- Adoport
Lek, Slovenia - Adoport 0,5 mg
Sandoz, Turkey - Adoport 1 mg
Sandoz, Turkey - Adoport 5 mg
Sandoz, Turkey - Advagraf
Astellas, Bosnia & Herzegowina; Astellas, Canada; Astellas, Estonia; Astellas, Georgia; Astellas, Hong Kong; Astellas, Croatia (Hrvatska); Astellas, Iceland; Astellas, Italy; Astellas, Latvia; Astellas, Norway; Astellas, Philippines; Astellas, Portugal; Astellas, Romania; Astellas, Russian Federation; Astellas, Slovakia; Astellas, Taiwan; Astellas, South Africa; Astellas Pharma, Poland; Astellas Pharma, Serbia; Astellas Pharma China, China; Astellas Pharma Europe, Netherlands; Astellas Pharma Europe BV, Greece; DKSH, Malaysia - Advagraf 0,5 mg
Astellas, Turkey - Advagraf 0,5 mg retard
Astellas, Hungary - Advagraf 0.5mg
Astellas, Switzerland - Advagraf 1 mg
Astellas, Turkey - Advagraf 1 mg retard
Astellas, Hungary - Advagraf 1mg
Astellas, Switzerland - Advagraf 3 mg retard
Astellas, Hungary - Advagraf 3mg
Astellas, Switzerland - Advagraf 5 mg
Astellas, Turkey - Advagraf 5 mg retard
Astellas, Hungary; Astellas Pharma, Germany - Advagraf 5mg
Astellas, Switzerland - Advagraf LP
Hikma, Tunisia - Advagraf PR
Astellas Pharma, Cyprus - Advagraf Prolonged Release
Astellas, Slovenia - Advagraf XL
Astellas Pharma, Australia - Astagraf XL
Astellas, United States - Atolimus
Beximco, Bangladesh - Cellmune 0.1%
Industrial Farmaceutica Cantabria, United Kingdom - Cidimus
Novartis, Chile; Sandoz, Poland - Cromus
Procaps, Colombia - Cromus Ung
Unimed, Peru - Dermitopic 0.1%
Pharmaswiss Ceska Republika, United Kingdom - Effac
Meider, Taiwan - Envarsus
Chiesi, Greece; Chiesi, Lithuania; Chiesi Farmaceutici, Slovenia; Chiesi Pharmaceuticals, Bosnia & Herzegowina; Chiesi Pharmaceuticals, Poland; Providens, Croatia (Hrvatska) - Envarsus 0.75 mg retard
Chiesi, Hungary - Envarsus 1 mg retard
Chiesi, Hungary - Envarsus LP
Chiesi, France - Envarsus XR
Veloxis Pharmaceuticals, United States - Gecrol
Heaton, Czech Republic; Heaton, Slovakia - Imugraft 0.5
Ambica, Philippines - Lecron
PharOS, Italy - Limus
Alco, Bangladesh - Modigraf
Astellas, Lithuania; Astellas, Slovenia; Astellas, Slovakia; Astellas Pharma, Germany; Astellas Pharma, Denmark; Astellas Pharma Europe, Iceland; Orifarm, Norway - Modigraf 0.2 mg
Astellas, Switzerland; Astellas, Hungary - Modigraf 1 mg
Astellas, Hungary - Modigraf 1mg
Astellas, Switzerland - Mustopic
Systopic, India - Norgraf
Nordic, Peru - Oligma
Eczacibasi Ilac Pazarlama, Turkey - Pacrolim
Alphapharm, Australia - Panolimus
Biem, Turkey - Proalid
Italmex, Mexico - Prodermic
Iqfarma, Peru - Produke
Titan, Georgia - Produke SR
Titan, Georgia - Prograf
Astellas, Bosnia & Herzegowina; Astellas, Canada; Astellas, Czech Republic; Astellas, Egypt; Astellas, Georgia; Astellas, Greece; Astellas, Hong Kong; Astellas, Indonesia; Astellas, Israel; Astellas, Italy; Astellas, South Korea; Astellas, Macedonia; Astellas, Malta; Astellas, Philippines; Astellas, Portugal; Astellas, Sweden; Astellas, Slovakia; Astellas, Thailand; Astellas, Turkey; Astellas, Taiwan; Astellas, United States; Astellas, South Africa; Astellas Pahrmaceuticals Aebe, Cyprus; Astellas Pharma, Australia; Astellas Pharma, Denmark; Astellas Pharma, United Kingdom; Astellas Pharma, Poland; Astellas Pharma, Singapore; Astellas Pharma a/s, Iceland; Astellas Pharma China, China; Astellas Pharma Europe, Romania; Astellas Pharma Singapore, Vietnam; DKSH, Malaysia; Farmagon, Norway; Gador, Argentina; Gador, Chile; Gador, Paraguay; Hikma, Kuwait; Hikma, Lebanon; Hikma, Oman; Hikma, Tunisia; Janssen, Venezuela; Janssen-Cilag, Brazil; Orifarm, Norway - Prograf 0.5 mg
Astellas, Hungary - Prograf 0.5mg
Astellas, Switzerland; Astellas, Israel; Gador, Uruguay - Prograf 1 mg
Astellas, Hungary - Prograf 1mg
APS, Switzerland; Astellas, Switzerland; Astellas, Israel - Prograf 5 mg
Astellas, Hungary - Prograf 5 mg/ml
Astellas, Hungary - Prograf 5mg
Astellas, Switzerland; Astellas, Israel; Gador, Uruguay - Prograf 5mg/ml
Astellas, Switzerland; Astellas Pharma, Austria; Astellas Pharma, Germany - Prograf XL
Astellas Pharma, Australia; Gador, Argentina; Gador, Chile - Protopic
Astellas, Georgia; Astellas, Greece; Astellas, Hong Kong; Astellas, Italy; Astellas, Portugal; Astellas, Taiwan; Astellas Ireland, Serbia; Astellas Pharma China, China; Janssen, Malaysia; Janssen, Philippines; Janssen, Singapore; Janssen-Cilag/Astellas, Indonesia; LEO, Norway; LEO Pharma, Canada; LEO Pharma, Greece; LEO Pharma, Lithuania; LEO Pharma, Latvia; LEO Pharma, Turkey; LEO Pharma, United States; Leofarma, Brazil; Roche Uruguay, Uruguay - Protopic 0.01%
Astellas, Croatia (Hrvatska) - Protopic 0.03%
Astellas, Switzerland; Astellas, Croatia (Hrvatska); Astellas, Israel; Astellas Pharma, Cyprus; Astellas Pharma, Poland; LEO Pharma, Spain; LEO Pharma, Netherlands - Protopic 0.1%
Astellas, Israel; Astellas Pharma, Cyprus; LEO Pharma, Switzerland; LEO Pharma, Netherlands; Leo Pharma A/S, Iceland - Protopy
Astellas, Lithuania - Regraf
MMC, Georgia - Remus
Square, Bangladesh - Rocimus
Mega Lifesciences, Philippines - Seegraf
Micro Labs, India - Tacloran
Wockhardt, India - Tacni
Pliva, Bosnia & Herzegowina; Pliva, Croatia (Hrvatska); Teva, Czech Republic; Teva, Spain; Teva, Greece; Teva, Lithuania; Teva, Norway; Teva Pharma, Cyprus; Teva Pharma, Slovenia; Teva Pharmaceuticals, Poland - Tacni 0.5mg
ratiopharm Arzneimittel, Austria; Teva, Germany; Teva, Hungary; Teva, Luxembourg; Teva Pharma, Switzerland - Tacni 1mg
ratiopharm Arzneimittel, Austria; Teva, Germany; Teva, Hungary; Teva, Luxembourg; Teva Pharma, Switzerland - Tacni 5mg
ratiopharm Arzneimittel, Austria; Teva, Germany; Teva, Hungary; Teva, Luxembourg; Teva Pharma, Switzerland - Tacpan 0,5mg
Panacea Biotec Germany, Germany - Tacpan 1mg
Panacea Biotec Germany, Germany - Tacpan 5mg
Panacea Biotec Germany, Germany - Tacroderm
AHPL, India - Tacrograf
Biocon, India - Tacrol
Acme, Bangladesh - Tacroli
Hwang's, Taiwan - Tacrolim
Incepta, Bangladesh - Tacrolimus
Accord Healthcare, United States; Belcher Pharmaceuticals, United States; Dr. Reddy's, United States; Fougera, United States; Hospira, United States; Lek, Bosnia & Herzegowina; Mylan, United States; Panacea Biotec, United States; Sandoz, United States; Strides Pharma, United States - Tacrolimus Accord
Accord, Lithuania; Accord Healthcare, Poland - Tacrolimus Accord 0.1%
Accord Healthcare, United Kingdom - Tacrolimus Accord Healthcare
Accord Healthcare, Italy - Tacrolimus Cinfa
Cinfa, Spain - Tacrolimus Medis
Medis, Tunisia - Tacrolimus Mylan
Mylan, Spain - Tacrolimus Pharma Arte
Pharma Arte, Paraguay - Tacrolimus PharmaSwiss
PharmaSwiss, Estonia; PharmaSwiss, Lithuania - Tacrolimus Pierre Fabre 0.1%
Pierre Fabre, United Kingdom - Tacrolimus Sandoz
Novartis, New Zealand; Sandoz, Hong Kong - Tacrolimus Servimedic
Servimedic, Uruguay - Tacrolimus Stada
STADA, Spain - Tacrolimus Teva 0.1%
Teva Pharmaceuticals, United Kingdom - Tacrolin
Farma-Tek, Turkey - Tacromus
Zydus Cadila, India - Tacrotec
Marzan Pharma, Philippines - Tacrotopic
Lafedar, Argentina - Tacroz
Glenmark, Ecuador; Glenmark, India; Glenmark Pharmaceuticals, Vietnam - Tacroz Forte
Glenmark, Ecuador; Glenmark, India; Glenmark, Peru; Glenmark Pharmaceuticals, Vietnam - Tagraf
Panacea Biotech, Philippines - Takrocept
Intas, Poland - Takrolimus Belupo
Belupo, Croatia (Hrvatska) - Takrolimus Genera
Genera, Croatia (Hrvatska) - Takrolimus Sandoz
Lek, Serbia - Taliximun
PharmaSwiss, Poland - Tames
Olcare Laboratories, India - Tarfic
Libbs, Brazil - Tarolimus 0.03%
Andalous, Egypt - Tartrime
Gobbi-Novag, Argentina; Juste, Spain - T-Inmun
Complex Therapeutics, Chile; Mediderm, Chile; Recalcine, Ecuador; Recalcine, Paraguay - Topgraf
GlaxoSmithKline, India - Topiclin
Solebio, Turkey - Tracsus
Alvogen, Croatia (Hrvatska); Alvogen Luxembourg, Romania; Cinfa, Macedonia; Laboratorios Cinfa, Bosnia & Herzegowina - Traderma
Serral, Mexico - T-Top
Wallace, India - T-Top Forte
Wallace, India - Vingraf
Emcure Pharma, Philippines - Adoport
Sandoz, Belgium; Sandoz, Portugal; Sandoz España, Spain - Adoport 0,5 mg
Sandoz, France; Sandoz, United Kingdom - Adoport 0.75 mg
Sandoz, United Kingdom - Adoport 1 mg
Sandoz, France; Sandoz, United Kingdom - Adoport 2 mg
Sandoz, France; Sandoz, United Kingdom - Adoport 5 mg
Sandoz, France; Sandoz, United Kingdom - Adport
Sandoz, Denmark; Sandoz, Georgia; Sandoz, Netherlands; Sandoz, Sweden - Adport 0,5 mg
Sandoz, Austria - Adport 1 mg
Sandoz, Austria - Adport 2 mg
Sandoz, Austria - Adport 5 mg
Sandoz, Austria - Advagraf
Astellas, Czech Republic; Astellas, Spain; Astellas, Finland; Astellas, Ireland; Astellas, South Korea; Astellas, Lithuania; Astellas, Sweden; Astellas, Thailand; Astellas Pharma, Belgium; Astellas Pharma, Denmark; Astellas Pharma, Singapore; Astellas Pharma Singapore, Vietnam - Advagraf 0,5 mg
Astellas, France - Advagraf 0,5 mg retard
Abacus, Austria; Astellas Pharma, Germany; Astellas Pharma Europe, Austria; Haemato Pharm, Austria - Advagraf 0.5mg
Astellas, Israel - Advagraf 0.5mg prolonged-release
Astellas Pharma, United Kingdom - Advagraf 1 mg
Astellas, France - Advagraf 1 mg prolonged-release
Astellas Pharma, United Kingdom - Advagraf 1 mg retard
Astellas Pharma, Germany; Astellas Pharma Europe, Austria - Advagraf 3 mg prolonged-release
Astellas Pharma, United Kingdom - Advagraf 3 mg retard
Astellas Pharma, Germany - Advagraf 3mg
Astellas, France - Advagraf 5 mg
Astellas, France - Advagraf 5 mg prolonged-release
Astellas Pharma, United Kingdom - Advagraf 5 mg retard
Abacus, Austria; Astellas Pharma Europe, Austria; Emra-Med Arzneimittel, Austria - Advagraf-0.5
Astellas, Luxembourg - Advagraf-1
Astellas, Luxembourg - Advagraf-3
Astellas, Luxembourg - Advagraf-5
Astellas, Luxembourg - Crilomus
Hexal, Germany - Crilomus 0.5mg
Sandoz, Switzerland - Crilomus 0.75mg
Sandoz, Switzerland - Crilomus 1mg
Sandoz, Switzerland - Crilomus 2mg
Sandoz, Switzerland - Crilomus 5mg
Sandoz, Switzerland - Dermitopic 0.1%
PharmaSwiss, Poland - Envarsus
Chiesi, Czech Republic; Chiesi, Germany; Chiesi, Denmark; Chiesi, Estonia; Chiesi, Spain; Chiesi, United Kingdom; Chiesi, Ireland; Chiesi, Norway; Chiesi, Sweden; Chiesi Farmaceutici, Netherlands; Chiesi Pharma, Finland - Envarsus 0.75mg
Chiesi, Switzerland; Chiesi Farmaceutici, Austria - Envarsus 1mg
Chiesi, Switzerland; Chiesi Farmaceutici, Austria - Envarsus 4mg
Chiesi, Switzerland; Chiesi Farmaceutici, Austria - Framebin
Pisa, Mexico - Graceptor
Astellas, Japan - Limustin
Landsteiner, Mexico - Modigraf
Astellas, Czech Republic; Astellas, Estonia; Astellas, Spain; Astellas, Finland; Astellas, France; Astellas, Ireland; Astellas, Latvia; Astellas, Norway; Astellas, Sweden; Astellas Pharma, United Kingdom; Astellas Pharma, Poland; Astellas Pharma Europe, Netherlands - Modigraf 0,2mg
Astellas Pharma Europe, Austria - Modigraf 1mg
Astellas Pharma Europe, Austria - Octralin
Raam, Mexico - Pharmacor Tacrolimus
Pharmacor, Australia - Prograf
Astellas, Bulgaria; Astellas, Spain; Astellas, Finland; Astellas, France; Astellas, Croatia (Hrvatska); Astellas, Ireland; Astellas, Japan; Astellas, South Korea; Astellas, Malta; Astellas, Norway; Astellas, Sweden; Astellas Ireland, Serbia; Astellas Pharma, United Kingdom; Janssen-Cilag, Mexico - Prograf 0,5mg
Astellas Pharma, Austria; Astellas Pharma, Germany - Prograf 1mg
Astellas Pharma, Austria; Astellas Pharma, Germany - Prograf 5mg
Astellas Pharma, Austria; Astellas Pharma, Germany - Prograf XL
Janssen-Cilag, Mexico - Prograft
Astellas, Belgium; Astellas Pharma Europe, Netherlands; BModesto, Netherlands; Delphi, Netherlands; Dr. Fisher Farma, Netherlands; EU-Pharma, Netherlands; Euro Registratie, Netherlands; Medcor Pharmaceuticals, Netherlands - Prograft-0.5
Astellas, Luxembourg - Prograft-1
Astellas, Luxembourg - Prograft-5
Astellas, Luxembourg - Protopic
Astellas, South Korea; Astellas, South Africa; Hikma, Oman; Janssen, Thailand; LEO, Ireland; LEO Pharma, Czech Republic; LEO Pharma, Denmark; LEO Pharma, Estonia; LEO Pharma, Finland; LEO Pharma, Sweden; Productos Roche, Chile; Roche, Ecuador; Roche, Mexico - Protopic 0.03%
Astellas, Japan; Astellas, Slovakia; Eurim-Pharm, Austria; LEO, Germany; LEO Laboratories, United Kingdom; Leo Pharma, Austria; Leo Pharma, Belgium; Leo Pharma, Finland; Leo Pharma, France; Leo Pharma, Hungary; Leo Pharma, Luxembourg; Leo Pharma, Romania - Protopic 0.1%
Astellas, Japan; Astellas, Slovakia; Astellas Pharma, Poland; Eurim-Pharm, Austria; LEO, Germany; LEO Laboratories, United Kingdom; Leo Pharma, Austria; Leo Pharma, France; Leo Pharma, Hungary; Leo Pharma, Luxembourg; Leo Pharma, Romania - Sandoz Tacrolimus
Sandoz, Canada - Tacforius
Teva Nederland, Netherlands - Tacni
Pharmachemie, Netherlands; Teva, Sweden - Tacrobell
Chong Kun Dang, South Korea - Tacrocel
Sandoz, Croatia (Hrvatska) - Tacrocel 0.5mg
LEK Pharmaceuticals, Israel - Tacrocel 1mg
LEK Pharmaceuticals, Israel - Tacrocel 5mg
LEK Pharmaceuticals, Israel - Tacrocin
Intas, Philippines - Tacroderm
Lazar, Argentina - Tacrolimus
Ayumi Pharmaceutical, Japan; Mylan Seiyaku, Japan; Nichi-Iko Pharmaceutical, Japan; Nihon Generic, Japan; Nipro, Japan; Sandoz, Argentina; Sandoz, Georgia; Towa Yakuhin, Japan; Nipro Pharma Nipurofama, Japan - Tacrolimus 0.1%
Iwaki Seiyaku, Japan; Pola Pharma, Japan; Takata Pharmaceutical, Japan; Nipro Pharma Nipurofama, Japan - Tacrolimus Accord
Accord Healthcare, Netherlands; Lyomark Pharma, Germany - Tacrolimus AL
Aliud Pharma, Germany - Tacrolimus Apotex
Pharmacor, Australia - Tacrolimus CF
Centrafarm, Netherlands - Tacrolimus Heumann
Heumann, Germany - Tacrolimus HEXAL
Hexal, Germany - Tacrolimus Lek
LEK farmacevtska, Macedonia - Tacrolimus Pergamus
Accord Healthcare, Bulgaria; Actavis, Bulgaria - Tacrolimus Sandoz
Sandoz, Australia; Sandoz, Netherlands; Sandoz, Romania; STADA, Spain - Takrozem
Pierre Fabre, Netherlands - Talymus 0.1%
Senju Seiyaku, Japan - Tarimus
Hanmi, South Korea
Glossary
| Term | Definition |
|---|---|
| BAN | British Approved Name |
| IS | Inofficial Synonym |
| JAN | Japanese Accepted Name |
| OS | Official Synonym |
| PH | Pharmacopoeia Name |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
Further information on drug naming conventions: International Nonproprietary Names.
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Further information
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