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Tacrolimus (International)

In the US, Tacrolimus (tacrolimus systemic) is a member of the drug class calcineurin inhibitors and is used to treat Crohn's Disease, Graft-versus-host disease, Nephrotic Syndrome, Organ Transplant - Rejection Prophylaxis and Organ Transplant - Rejection Reversal.

US matches:

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

D11AH01,L04AA05,L04AD02

CAS registry number (Chemical Abstracts Service)

0104987-11-3

Chemical Formula

C44-H69-N-O12

Molecular Weight

804

Therapeutic Category

Immunosuppressant

Chemical Name

Immunosuppre╬▓ant derived from Streptomyces tsukubaensis

Foreign Names

  • Tacrolimusum (Latin)
  • Tacrolimus (German)
  • Tacrolimus (French)
  • Tacrolimus (Spanish)

Generic Names

  • Tacrolimus (OS: USAN, BAN)
  • Tacrolimus (PH: USP 41)
  • Tacrolimus Hydrate (OS: JAN)
  • FK 506 (Fujisawa) (IS)
  • FR 900506 (IS)
  • L 683590 (IS)
  • Tacrolimus Hydrate (PH: JP XVII)
  • Tacrolimus Monohydrate (PH: BP 2018, Ph. Eur. 9.3)

Brand Names

  • Adoport
    Lek, Slovenia
  • Adoport 0,5 mg
    Sandoz, Turkey
  • Adoport 1 mg
    Sandoz, Turkey
  • Adoport 5 mg
    Sandoz, Turkey
  • Advagraf
    Astellas, Bosnia & Herzegowina; Astellas, Canada; Astellas, Estonia; Astellas, Georgia; Astellas, Hong Kong; Astellas, Croatia (Hrvatska); Astellas, Iceland; Astellas, Italy; Astellas, Latvia; Astellas, Norway; Astellas, Philippines; Astellas, Portugal; Astellas, Romania; Astellas, Russian Federation; Astellas, Slovakia; Astellas, Taiwan; Astellas, South Africa; Astellas Pharma, Poland; Astellas Pharma, Serbia; Astellas Pharma China, China; Astellas Pharma Europe, Netherlands; Astellas Pharma Europe BV, Greece; DKSH, Malaysia
  • Advagraf 0,5 mg
    Astellas, Turkey
  • Advagraf 0,5 mg retard
    Astellas, Hungary
  • Advagraf 0.5mg
    Astellas, Switzerland
  • Advagraf 1 mg
    Astellas, Turkey
  • Advagraf 1 mg retard
    Astellas, Hungary
  • Advagraf 1mg
    Astellas, Switzerland
  • Advagraf 3 mg retard
    Astellas, Hungary
  • Advagraf 3mg
    Astellas, Switzerland
  • Advagraf 5 mg
    Astellas, Turkey
  • Advagraf 5 mg retard
    Astellas, Hungary; Astellas Pharma, Germany
  • Advagraf 5mg
    Astellas, Switzerland
  • Advagraf LP
    Hikma, Tunisia
  • Advagraf PR
    Astellas Pharma, Cyprus
  • Advagraf Prolonged Release
    Astellas, Slovenia
  • Advagraf XL
    Astellas Pharma, Australia
  • Astagraf XL
    Astellas, United States
  • Atolimus
    Beximco, Bangladesh
  • Cellmune 0.1%
    Industrial Farmaceutica Cantabria, United Kingdom
  • Cidimus
    Novartis, Chile; Sandoz, Poland
  • Cromus
    Procaps, Colombia
  • Cromus Ung
    Unimed, Peru
  • Dermitopic 0.1%
    Pharmaswiss Ceska Republika, United Kingdom
  • Effac
    Meider, Taiwan
  • Envarsus
    Chiesi, Greece; Chiesi, Lithuania; Chiesi Farmaceutici, Slovenia; Chiesi Pharmaceuticals, Bosnia & Herzegowina; Chiesi Pharmaceuticals, Poland; Providens, Croatia (Hrvatska)
  • Envarsus 0.75 mg retard
    Chiesi, Hungary
  • Envarsus 1 mg retard
    Chiesi, Hungary
  • Envarsus LP
    Chiesi, France
  • Envarsus XR
    Veloxis Pharmaceuticals, United States
  • Gecrol
    Heaton, Czech Republic; Heaton, Slovakia
  • Imugraft 0.5
    Ambica, Philippines
  • Lecron
    PharOS, Italy
  • Limus
    Alco, Bangladesh
  • Modigraf
    Astellas, Lithuania; Astellas, Slovenia; Astellas, Slovakia; Astellas Pharma, Germany; Astellas Pharma, Denmark; Astellas Pharma Europe, Iceland; Orifarm, Norway
  • Modigraf 0.2 mg
    Astellas, Switzerland; Astellas, Hungary
  • Modigraf 1 mg
    Astellas, Hungary
  • Modigraf 1mg
    Astellas, Switzerland
  • Mustopic
    Systopic, India
  • Norgraf
    Nordic, Peru
  • Oligma
    Eczacibasi Ilac Pazarlama, Turkey
  • Pacrolim
    Alphapharm, Australia
  • Panolimus
    Biem, Turkey
  • Proalid
    Italmex, Mexico
  • Prodermic
    Iqfarma, Peru
  • Produke
    Titan, Georgia
  • Produke SR
    Titan, Georgia
  • Prograf
    Astellas, Bosnia & Herzegowina; Astellas, Canada; Astellas, Czech Republic; Astellas, Egypt; Astellas, Georgia; Astellas, Greece; Astellas, Hong Kong; Astellas, Indonesia; Astellas, Israel; Astellas, Italy; Astellas, South Korea; Astellas, Macedonia; Astellas, Malta; Astellas, Philippines; Astellas, Portugal; Astellas, Sweden; Astellas, Slovakia; Astellas, Thailand; Astellas, Turkey; Astellas, Taiwan; Astellas, United States; Astellas, South Africa; Astellas Pahrmaceuticals Aebe, Cyprus; Astellas Pharma, Australia; Astellas Pharma, Denmark; Astellas Pharma, United Kingdom; Astellas Pharma, Poland; Astellas Pharma, Singapore; Astellas Pharma a/s, Iceland; Astellas Pharma China, China; Astellas Pharma Europe, Romania; Astellas Pharma Singapore, Vietnam; DKSH, Malaysia; Farmagon, Norway; Gador, Argentina; Gador, Chile; Gador, Paraguay; Hikma, Kuwait; Hikma, Lebanon; Hikma, Oman; Hikma, Tunisia; Janssen, Venezuela; Janssen-Cilag, Brazil; Orifarm, Norway
  • Prograf 0.5 mg
    Astellas, Hungary
  • Prograf 0.5mg
    Astellas, Switzerland; Astellas, Israel; Gador, Uruguay
  • Prograf 1 mg
    Astellas, Hungary
  • Prograf 1mg
    APS, Switzerland; Astellas, Switzerland; Astellas, Israel
  • Prograf 5 mg
    Astellas, Hungary
  • Prograf 5 mg/ml
    Astellas, Hungary
  • Prograf 5mg
    Astellas, Switzerland; Astellas, Israel; Gador, Uruguay
  • Prograf 5mg/ml
    Astellas, Switzerland; Astellas Pharma, Austria; Astellas Pharma, Germany
  • Prograf XL
    Astellas Pharma, Australia; Gador, Argentina; Gador, Chile
  • Protopic
    Astellas, Georgia; Astellas, Greece; Astellas, Hong Kong; Astellas, Italy; Astellas, Portugal; Astellas, Taiwan; Astellas Ireland, Serbia; Astellas Pharma China, China; Janssen, Malaysia; Janssen, Philippines; Janssen, Singapore; Janssen-Cilag/Astellas, Indonesia; LEO, Norway; LEO Pharma, Canada; LEO Pharma, Greece; LEO Pharma, Lithuania; LEO Pharma, Latvia; LEO Pharma, Turkey; LEO Pharma, United States; Leofarma, Brazil; Roche Uruguay, Uruguay
  • Protopic 0.01%
    Astellas, Croatia (Hrvatska)
  • Protopic 0.03%
    Astellas, Switzerland; Astellas, Croatia (Hrvatska); Astellas, Israel; Astellas Pharma, Cyprus; Astellas Pharma, Poland; LEO Pharma, Spain; LEO Pharma, Netherlands
  • Protopic 0.1%
    Astellas, Israel; Astellas Pharma, Cyprus; LEO Pharma, Switzerland; LEO Pharma, Netherlands; Leo Pharma A/S, Iceland
  • Protopy
    Astellas, Lithuania
  • Regraf
    MMC, Georgia
  • Remus
    Square, Bangladesh
  • Rocimus
    Mega Lifesciences, Philippines
  • Seegraf
    Micro Labs, India
  • Tacloran
    Wockhardt, India
  • Tacni
    Pliva, Bosnia & Herzegowina; Pliva, Croatia (Hrvatska); Teva, Czech Republic; Teva, Spain; Teva, Greece; Teva, Lithuania; Teva, Norway; Teva Pharma, Cyprus; Teva Pharma, Slovenia; Teva Pharmaceuticals, Poland
  • Tacni 0.5mg
    ratiopharm Arzneimittel, Austria; Teva, Germany; Teva, Hungary; Teva, Luxembourg; Teva Pharma, Switzerland
  • Tacni 1mg
    ratiopharm Arzneimittel, Austria; Teva, Germany; Teva, Hungary; Teva, Luxembourg; Teva Pharma, Switzerland
  • Tacni 5mg
    ratiopharm Arzneimittel, Austria; Teva, Germany; Teva, Hungary; Teva, Luxembourg; Teva Pharma, Switzerland
  • Tacpan 0,5mg
    Panacea Biotec Germany, Germany
  • Tacpan 1mg
    Panacea Biotec Germany, Germany
  • Tacpan 5mg
    Panacea Biotec Germany, Germany
  • Tacroderm
    AHPL, India
  • Tacrograf
    Biocon, India
  • Tacrol
    Acme, Bangladesh
  • Tacroli
    Hwang's, Taiwan
  • Tacrolim
    Incepta, Bangladesh
  • Tacrolimus
    Accord Healthcare, United States; Belcher Pharmaceuticals, United States; Dr. Reddy's, United States; Fougera, United States; Hospira, United States; Lek, Bosnia & Herzegowina; Mylan, United States; Panacea Biotec, United States; Sandoz, United States; Strides Pharma, United States
  • Tacrolimus Accord
    Accord, Lithuania; Accord Healthcare, Poland
  • Tacrolimus Accord 0.1%
    Accord Healthcare, United Kingdom
  • Tacrolimus Accord Healthcare
    Accord Healthcare, Italy
  • Tacrolimus Cinfa
    Cinfa, Spain
  • Tacrolimus Medis
    Medis, Tunisia
  • Tacrolimus Mylan
    Mylan, Spain
  • Tacrolimus Pharma Arte
    Pharma Arte, Paraguay
  • Tacrolimus PharmaSwiss
    PharmaSwiss, Estonia; PharmaSwiss, Lithuania
  • Tacrolimus Pierre Fabre 0.1%
    Pierre Fabre, United Kingdom
  • Tacrolimus Sandoz
    Novartis, New Zealand; Sandoz, Hong Kong
  • Tacrolimus Servimedic
    Servimedic, Uruguay
  • Tacrolimus Stada
    STADA, Spain
  • Tacrolimus Teva 0.1%
    Teva Pharmaceuticals, United Kingdom
  • Tacrolin
    Farma-Tek, Turkey
  • Tacromus
    Zydus Cadila, India
  • Tacrotec
    Marzan Pharma, Philippines
  • Tacrotopic
    Lafedar, Argentina
  • Tacroz
    Glenmark, Ecuador; Glenmark, India; Glenmark Pharmaceuticals, Vietnam
  • Tacroz Forte
    Glenmark, Ecuador; Glenmark, India; Glenmark, Peru; Glenmark Pharmaceuticals, Vietnam
  • Tagraf
    Panacea Biotech, Philippines
  • Takrocept
    Intas, Poland
  • Takrolimus Belupo
    Belupo, Croatia (Hrvatska)
  • Takrolimus Genera
    Genera, Croatia (Hrvatska)
  • Takrolimus Sandoz
    Lek, Serbia
  • Taliximun
    PharmaSwiss, Poland
  • Tames
    Olcare Laboratories, India
  • Tarfic
    Libbs, Brazil
  • Tarolimus 0.03%
    Andalous, Egypt
  • Tartrime
    Gobbi-Novag, Argentina; Juste, Spain
  • T-Inmun
    Complex Therapeutics, Chile; Mediderm, Chile; Recalcine, Ecuador; Recalcine, Paraguay
  • Topgraf
    GlaxoSmithKline, India
  • Topiclin
    Solebio, Turkey
  • Tracsus
    Alvogen, Croatia (Hrvatska); Alvogen Luxembourg, Romania; Cinfa, Macedonia; Laboratorios Cinfa, Bosnia & Herzegowina
  • Traderma
    Serral, Mexico
  • T-Top
    Wallace, India
  • T-Top Forte
    Wallace, India
  • Vingraf
    Emcure Pharma, Philippines
  • Adoport
    Sandoz, Belgium; Sandoz, Portugal; Sandoz Espa├▒a, Spain
  • Adoport 0,5 mg
    Sandoz, France; Sandoz, United Kingdom
  • Adoport 0.75 mg
    Sandoz, United Kingdom
  • Adoport 1 mg
    Sandoz, France; Sandoz, United Kingdom
  • Adoport 2 mg
    Sandoz, France; Sandoz, United Kingdom
  • Adoport 5 mg
    Sandoz, France; Sandoz, United Kingdom
  • Adport
    Sandoz, Denmark; Sandoz, Georgia; Sandoz, Netherlands; Sandoz, Sweden
  • Adport 0,5 mg
    Sandoz, Austria
  • Adport 1 mg
    Sandoz, Austria
  • Adport 2 mg
    Sandoz, Austria
  • Adport 5 mg
    Sandoz, Austria
  • Advagraf
    Astellas, Czech Republic; Astellas, Spain; Astellas, Finland; Astellas, Ireland; Astellas, South Korea; Astellas, Lithuania; Astellas, Sweden; Astellas, Thailand; Astellas Pharma, Belgium; Astellas Pharma, Denmark; Astellas Pharma, Singapore; Astellas Pharma Singapore, Vietnam
  • Advagraf 0,5 mg
    Astellas, France
  • Advagraf 0,5 mg retard
    Abacus, Austria; Astellas Pharma, Germany; Astellas Pharma Europe, Austria; Haemato Pharm, Austria
  • Advagraf 0.5mg
    Astellas, Israel
  • Advagraf 0.5mg prolonged-release
    Astellas Pharma, United Kingdom
  • Advagraf 1 mg
    Astellas, France
  • Advagraf 1 mg prolonged-release
    Astellas Pharma, United Kingdom
  • Advagraf 1 mg retard
    Astellas Pharma, Germany; Astellas Pharma Europe, Austria
  • Advagraf 3 mg prolonged-release
    Astellas Pharma, United Kingdom
  • Advagraf 3 mg retard
    Astellas Pharma, Germany
  • Advagraf 3mg
    Astellas, France
  • Advagraf 5 mg
    Astellas, France
  • Advagraf 5 mg prolonged-release
    Astellas Pharma, United Kingdom
  • Advagraf 5 mg retard
    Abacus, Austria; Astellas Pharma Europe, Austria; Emra-Med Arzneimittel, Austria
  • Advagraf-0.5
    Astellas, Luxembourg
  • Advagraf-1
    Astellas, Luxembourg
  • Advagraf-3
    Astellas, Luxembourg
  • Advagraf-5
    Astellas, Luxembourg
  • Crilomus
    Hexal, Germany
  • Crilomus 0.5mg
    Sandoz, Switzerland
  • Crilomus 0.75mg
    Sandoz, Switzerland
  • Crilomus 1mg
    Sandoz, Switzerland
  • Crilomus 2mg
    Sandoz, Switzerland
  • Crilomus 5mg
    Sandoz, Switzerland
  • Dermitopic 0.1%
    PharmaSwiss, Poland
  • Envarsus
    Chiesi, Czech Republic; Chiesi, Germany; Chiesi, Denmark; Chiesi, Estonia; Chiesi, Spain; Chiesi, United Kingdom; Chiesi, Ireland; Chiesi, Norway; Chiesi, Sweden; Chiesi Farmaceutici, Netherlands; Chiesi Pharma, Finland
  • Envarsus 0.75mg
    Chiesi, Switzerland; Chiesi Farmaceutici, Austria
  • Envarsus 1mg
    Chiesi, Switzerland; Chiesi Farmaceutici, Austria
  • Envarsus 4mg
    Chiesi, Switzerland; Chiesi Farmaceutici, Austria
  • Framebin
    Pisa, Mexico
  • Graceptor
    Astellas, Japan
  • Limustin
    Landsteiner, Mexico
  • Modigraf
    Astellas, Czech Republic; Astellas, Estonia; Astellas, Spain; Astellas, Finland; Astellas, France; Astellas, Ireland; Astellas, Latvia; Astellas, Norway; Astellas, Sweden; Astellas Pharma, United Kingdom; Astellas Pharma, Poland; Astellas Pharma Europe, Netherlands
  • Modigraf 0,2mg
    Astellas Pharma Europe, Austria
  • Modigraf 1mg
    Astellas Pharma Europe, Austria
  • Octralin
    Raam, Mexico
  • Pharmacor Tacrolimus
    Pharmacor, Australia
  • Prograf
    Astellas, Bulgaria; Astellas, Spain; Astellas, Finland; Astellas, France; Astellas, Croatia (Hrvatska); Astellas, Ireland; Astellas, Japan; Astellas, South Korea; Astellas, Malta; Astellas, Norway; Astellas, Sweden; Astellas Ireland, Serbia; Astellas Pharma, United Kingdom; Janssen-Cilag, Mexico
  • Prograf 0,5mg
    Astellas Pharma, Austria; Astellas Pharma, Germany
  • Prograf 1mg
    Astellas Pharma, Austria; Astellas Pharma, Germany
  • Prograf 5mg
    Astellas Pharma, Austria; Astellas Pharma, Germany
  • Prograf XL
    Janssen-Cilag, Mexico
  • Prograft
    Astellas, Belgium; Astellas Pharma Europe, Netherlands; BModesto, Netherlands; Delphi, Netherlands; Dr. Fisher Farma, Netherlands; EU-Pharma, Netherlands; Euro Registratie, Netherlands; Medcor Pharmaceuticals, Netherlands
  • Prograft-0.5
    Astellas, Luxembourg
  • Prograft-1
    Astellas, Luxembourg
  • Prograft-5
    Astellas, Luxembourg
  • Protopic
    Astellas, South Korea; Astellas, South Africa; Hikma, Oman; Janssen, Thailand; LEO, Ireland; LEO Pharma, Czech Republic; LEO Pharma, Denmark; LEO Pharma, Estonia; LEO Pharma, Finland; LEO Pharma, Sweden; Productos Roche, Chile; Roche, Ecuador; Roche, Mexico
  • Protopic 0.03%
    Astellas, Japan; Astellas, Slovakia; Eurim-Pharm, Austria; LEO, Germany; LEO Laboratories, United Kingdom; Leo Pharma, Austria; Leo Pharma, Belgium; Leo Pharma, Finland; Leo Pharma, France; Leo Pharma, Hungary; Leo Pharma, Luxembourg; Leo Pharma, Romania
  • Protopic 0.1%
    Astellas, Japan; Astellas, Slovakia; Astellas Pharma, Poland; Eurim-Pharm, Austria; LEO, Germany; LEO Laboratories, United Kingdom; Leo Pharma, Austria; Leo Pharma, France; Leo Pharma, Hungary; Leo Pharma, Luxembourg; Leo Pharma, Romania
  • Sandoz Tacrolimus
    Sandoz, Canada
  • Tacforius
    Teva Nederland, Netherlands
  • Tacni
    Pharmachemie, Netherlands; Teva, Sweden
  • Tacrobell
    Chong Kun Dang, South Korea
  • Tacrocel
    Sandoz, Croatia (Hrvatska)
  • Tacrocel 0.5mg
    LEK Pharmaceuticals, Israel
  • Tacrocel 1mg
    LEK Pharmaceuticals, Israel
  • Tacrocel 5mg
    LEK Pharmaceuticals, Israel
  • Tacrocin
    Intas, Philippines
  • Tacroderm
    Lazar, Argentina
  • Tacrolimus
    Ayumi Pharmaceutical, Japan; Mylan Seiyaku, Japan; Nichi-Iko Pharmaceutical, Japan; Nihon Generic, Japan; Nipro, Japan; Sandoz, Argentina; Sandoz, Georgia; Towa Yakuhin, Japan; Nipro Pharma Nipurofama, Japan
  • Tacrolimus 0.1%
    Iwaki Seiyaku, Japan; Pola Pharma, Japan; Takata Pharmaceutical, Japan; Nipro Pharma Nipurofama, Japan
  • Tacrolimus Accord
    Accord Healthcare, Netherlands; Lyomark Pharma, Germany
  • Tacrolimus AL
    Aliud Pharma, Germany
  • Tacrolimus Apotex
    Pharmacor, Australia
  • Tacrolimus CF
    Centrafarm, Netherlands
  • Tacrolimus Heumann
    Heumann, Germany
  • Tacrolimus HEXAL
    Hexal, Germany
  • Tacrolimus Lek
    LEK farmacevtska, Macedonia
  • Tacrolimus Pergamus
    Accord Healthcare, Bulgaria; Actavis, Bulgaria
  • Tacrolimus Sandoz
    Sandoz, Australia; Sandoz, Netherlands; Sandoz, Romania; STADA, Spain
  • Takrozem
    Pierre Fabre, Netherlands
  • Talymus 0.1%
    Senju Seiyaku, Japan
  • Tarimus
    Hanmi, South Korea

Glossary

TermDefinition
BANBritish Approved Name
ISInofficial Synonym
JANJapanese Accepted Name
OSOfficial Synonym
PHPharmacopoeia Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name

Further information on drug naming conventions: International Nonproprietary Names.

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Further information

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