Drug Interaction Report

Pegvaliase may cause severe allergic reactions, and using it together with other "PEGylated" medications (i.E., medications formulated with polyethylene glycol) may increase the risk. Some examples of PEGylated medications besides pegvaliase include: certolizumab pegol (Cimzia); doxorubicin liposomal (Doxil, Lipodox); eflapegrastim (Rolvedon); epoetin beta-methoxy polyethylene glycol (Mircera); irinotecan liposomal (Onivyde); medroxyprogesterone acetate injectable suspension (Depo-Provera); naloxegol (Movantik); pegademase bovine (Adagen); pegaptanib (Macugen); pegaspargase (Oncaspar); pegfilgrastim (Neulasta, Fulphila); peginesatide (Omontys); peginterferons (Pegasys, PEG-Intron, Sylatron, Plegridy); pegloticase (Krystexxa); pegvisomant (Somavert); and certain recombinant products used to treat hemophilia (Adynovate, Rebinyn). Before receiving treatment with pegvaliase, let your doctor know if you are currently using other PEGylated products such as coagulation factor IX. Your doctor will prescribe an auto-injectable epinephrine for you (or your caregiver) to administer in case you experience a severe allergic reaction during treatment with pegvaliase. You should stop using pegvaliase and seek immediate medical attention if you develop any of the following symptoms of a severe allergic reaction: fainting; dizziness or lightheadedness; sudden confusion; trouble breathing or wheezing; chest discomfort or tightness; rapid heart rate; swelling of your face, lips, eyes, or tongue; throat tightness; flushing; rash, itching, or raised bumps on skin; nausea, vomiting, or diarrhea; and incontinence. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.