Drug Interaction Report
1 drug interaction and 9 additional warnings found for the following 2 drugs:
- cilostazol
- treosulfan
Drug interactions
Moderate drug interactions
Moderate:cilostazol treosulfan
Applies to: cilostazol, treosulfan
Treosulfan may increase the blood levels and effects of cilostazol.
Contact your doctor if your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring to safely use both medications.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:Food/Lifestyle cilostazol
Applies to: cilostazol
Take cilostazol on an empty stomach 1 hour before or 2 hours after a meal unless otherwise directed by your doctor. Food may reduce the absorption of cilostazol. Taking cilostazol on an empty stomach will make it easier for your body to absorb the medication.
If you are receiving therapy with cilostazol you should avoid grapefruits and grapefruit juice. Grapefruit can raise the levels of cilostazol in your body and lead to dangerous side effects.
You may experience:
- headache
- dizziness
- chest pain
- feeling short of breath
- swelling of your ankles or feet
Call your doctor at once if you have any of these symptoms.
Disease interactions
8 potential interactionsApplies to: 7 conditions, including Heart Failure, Seizures, Liver Disease, Bleeding Disorder, and Ischemic Heart Disease.
Bleeding Disorder
Major:cilostazol
Cilostazol has a major potential interaction with Bleeding Disorder.
Cilostazol inhibits platelet aggregation in a reversible manner. Cilostazol has not been studied in patients with hemostatic disorders or active pathologic bleeding. Avoid use of cilostazol tablets in these patients.
Coagulation Defects and Disorders
Major:cilostazol
Cilostazol has a major potential interaction with Coagulation Defects and Disorders.
Cilostazol inhibits platelet aggregation in a reversible manner. Cilostazol has not been studied in patients with hemostatic disorders or active pathologic bleeding. Avoid use of cilostazol tablets in these patients.
Heart Failure
Major:cilostazol
Cilostazol has a major potential interaction with Heart Failure.
The use of cilostazol is contraindicated in patients with heart failure of any severity. Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with this pharmacologic effect have caused decreased survival compared to placebo in patients with class III- IV heart failure.
Ischemic Heart Disease
Moderate:cilostazol
Cilostazol has a moderate potential interaction with Ischemic Heart Disease.
Cilostazol may induce tachycardia, palpitation, tachyarrhythmia or hypotension. The increase in heart rate associated with cilostazol is approximately 5 to 7 bpm. Patients with a history of ischemic heart disease may be at risk for exacerbations of angina pectoris or myocardial infarction. Caution is advised.
Liver Disease
Moderate:cilostazol
Cilostazol has a moderate potential interaction with Liver Disease.
No cilostazol dose adjustment is required in patients with mild hepatic impairment. Patients with moderate or severe hepatic impairment have not been studied in clinical trials and dosing recommendations cannot be provided. Caution is advised if used in these patients.
Moderate:treosulfan
Treosulfan has a moderate potential interaction with Liver Disease.
Treosulfan has not been studied in patients with moderate or severe liver and renal dysfunction.
Renal Dysfunction
Moderate:treosulfan
Treosulfan has a moderate potential interaction with Renal Dysfunction.
Treosulfan has not been studied in patients with moderate or severe liver and renal dysfunction.
Seizures
Moderate:treosulfan
Treosulfan has a moderate potential interaction with Seizures.
There have been reports of seizures in patients following treatment with treosulfan. Patients should be monitored for signs of neurological adverse reactions, and clonazepam prophylaxis may be considered for patients at higher risk for seizures, including infants.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.