Drug Interaction Report

Levacetylleucine may increase the blood levels of cobimetinib. In some cases, this may increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, mouth sores, bleeding, heart problems (e.G., heart failure), rash, photosensitivity (i.E., increased sensitivity to sunlight), eye problems, liver injury, and muscle damage. Contact your doctor if your condition changes or you experience increased side effects. You may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Grapefruit juice may increase the blood levels and effects of certain medications such as cobimetinib. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with cobimetinib. However, if you have been regularly consuming grapefruit or grapefruit juice with cobimetinib, do not alter the amounts of these products in your diet without first talking to your doctor or other healthcare professional. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.