Drug Interaction Report

Tiludronate may alter the effects of palopegteriparatide in regulating the amount of calcium in your blood. You may need extra monitoring to safely use both drugs. Talk to your doctor if you have any questions or concerns. Contact your doctor promptly if your condition changes or you develop symptoms of high levels of calcium in the blood (hypercalcemia) such as nausea, vomiting, constipation, lethargy, muscle weakness. Likewise, contact your doctor as soon as possible if you develop symptoms of low levels of calcium in the blood (hypocalcemia) such as numbness or tingling around your mouth, muscle cramps, uncontrolled muscle movements, irritability, depression, irregular heartbeats, or confusion. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food significantly decreases the levels of tiludronate. Tiludronate should be administered on an empty stomach with 6 to 8 ounces of plain water at least 2 hours before or 2 hours after food. This will make it easier for your body to absorb the medication.