Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Apretude (cabotegravir)
- rifabutin
Interactions between your drugs
rifabutin cabotegravir
Applies to: rifabutin, Apretude (cabotegravir)
CONTRAINDICATED: Coadministration with rifabutin may decrease the plasma concentrations of cabotegravir. The mechanism of interaction has not been established. In 12 study subjects given cabotegravir 30 mg once daily with rifabutin 300 mg once daily, mean cabotegravir peak plasma concentration (Cmax) and systemic exposure (AUC) were reduced by 17% and 21%, respectively.
MANAGEMENT: If cabotegravir is prescribed in combination with rilpivirine, concomitant use of rifabutin is considered contraindicated by the manufacturer.
References (3)
- Cerner Multum, Inc. (2015) "Canadian Product Information."
- (2021) "Product Information. Cabenuva (cabotegravir-rilpivirine)." ViiV Healthcare ULC
- (2021) "Product Information. Vocabria (cabotegravir)." ViiV Healthcare
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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