Drug Interaction Report
10 potential interactions and/or warnings found for the following 2 drugs:
- Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)
- Guaphen II DM (dextromethorphan / guaifenesin / phenylephrine)
Interactions between your drugs
chlorpheniramine dextromethorphan
Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Guaphen II DM (dextromethorphan / guaifenesin / phenylephrine)
Using chlorpheniramine together with dextromethorphan may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
phenylephrine phenylpropanolamine
Applies to: Guaphen II DM (dextromethorphan / guaifenesin / phenylephrine), Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)
Both phenylephrine and phenylpropanolamine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
acetaminophen food
Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)
Ask your doctor before using acetaminophen together with ethanol. This can cause serious side effects that affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
chlorpheniramine food
Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)
Alcohol can increase the nervous system side effects of chlorpheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with chlorpheniramine. Do not use more than the recommended dose of chlorpheniramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
dextromethorphan food
Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine), Guaphen II DM (dextromethorphan / guaifenesin / phenylephrine)
Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dextromethorphan. Do not use more than the recommended dose of dextromethorphan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
phenylpropanolamine food
Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)
Using phenylpropanolamine with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. In addition, you may also be more likely to experience nervous system side effects such as dizziness, drowsiness, depression, and difficulty concentrating. You should avoid or limit the use of alcohol while being treated with phenylpropanolamine. Do not use more than the recommended dose of phenylpropanolamine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.
phenylephrine food
Applies to: Guaphen II DM (dextromethorphan / guaifenesin / phenylephrine)
Both phenylephrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
phenylpropanolamine food
Applies to: Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)
Both phenylpropanolamine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Decongestants
Therapeutic duplication
The recommended maximum number of medicines in the 'decongestants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'decongestants' category:
- Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)
- Guaphen II DM (dextromethorphan / guaifenesin / phenylephrine)
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
NMDA antagonists
Therapeutic duplication
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'NMDA antagonists' category:
- Comtrex Cold and Flu Maximum Strength (acetaminophen / chlorpheniramine / dextromethorphan / phenylpropanolamine)
- Guaphen II DM (dextromethorphan / guaifenesin / phenylephrine)
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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