Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- enasidenib
- Provera (medroxyprogesterone)
Interactions between your drugs
medroxyPROGESTERone enasidenib
Applies to: Provera (medroxyprogesterone), enasidenib
MONITOR: Coadministration with enasidenib may alter the plasma concentrations of hormonal contraceptives. In vitro, enasidenib has been found to both inhibit and induce CYP450 3A4, the isoenzyme primarily responsible for the metabolic clearance of contraceptive hormones. The clinical significance is unknown.
MANAGEMENT: Because use of enasidenib may be associated with fetal harm, it is important that patients not become pregnant during treatment. It may be advisable to monitor patients for potentially altered effects of their hormonal contraceptive during and after treatment with enasidenib. Input from a gynecologist or similar expert on adequate contraception, including emergency contraception, should be sought as needed. Intrauterine systems are unlikely to be significantly affected because of their local action.
References (1)
- (2017) "Product Information. Idhifa (enasidenib)." Celgene Corporation
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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