Drug Interaction Report

If you are currently being treated or have recently been treated with sirolimus, you should let your doctor know before receiving adenovirus vaccine, live. The use of adenovirus vaccine, live has not been adequately studied in patients receiving medications that affect the immune system, and it is not known whether you may have an increased risk of side effects or a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of sirolimus therapy. If you have recently been vaccinated with adenovirus vaccine, live, your doctor may choose to postpone treatment with sirolimus for a couple of weeks. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Grapefruit and grapefruit juice may interact with sirolimus and could lead to potentially dangerous effects. Avoid eating grapefruit or drinking grapefruit juice while you are taking sirolimus. Also, you should preferably take sirolimus at least one hour before eating. If you do take it with food, you should take it each time with food to avoid changes in sirolimus levels. The oral liquid form of sirolimus must be mixed with water or orange juice only. Do not use grapefruit juice to mix this medication.