Drug Interaction Report

Idelalisib may cause serious and life-threatening diarrhea, and using it with other medications that also commonly cause diarrhea such as miltefosine may increase that risk. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Call your doctor immediately if the number of bowel movements per day increases by six or more, or if you experience new or worsening abdominal pain, chills, fever, nausea, or vomiting. You may need a dose adjustment or an interruption in idelalisib therapy if you develop severe diarrhea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Taking miltefosine with food may help reduce gastrointestinal side effects such as nausea, vomiting, abdominal pain, and diarrhea. You should take each dose of miltefosine with your meals. Contact your doctor if you develop severe vomiting or diarrhea that does not go away. Drink plenty of fluids while you are experiencing nausea or vomiting to help prevent dehydration, which may increase the risk of kidney injury.