Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Ferriprox (deferiprone)
- probenecid
Interactions between your drugs
probenecid deferiprone
Applies to: probenecid, Ferriprox (deferiprone)
GENERALLY AVOID: Coadministration of deferiprone with uridine diphosphate glucuronosyltransferase (UGT) 1A6 inhibitors may increase the plasma concentrations of deferiprone, which is metabolized by the enzyme. An in vitro study has shown coadministration of deferiprone with phenylbutazone (UGT1A6 inhibitor) decreased glucuronidation to 3-O-glucuronide (the major inactive metabolite of deferiprone) by up to 78%.
MANAGEMENT: The use of deferiprone with UGT1A6 inhibitors should be avoided.
References (1)
- (2011) "Product Information. Ferriprox (deferiprone)." ApoPharma USA Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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