Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- deferiprone
- Dyloject (diclofenac)
Interactions between your drugs
diclofenac deferiprone
Applies to: Dyloject (diclofenac), deferiprone
GENERALLY AVOID: Coadministration of deferiprone with uridine diphosphate glucuronosyltransferase (UGT) 1A6 inhibitors may increase the plasma concentrations of deferiprone, which is metabolized by the enzyme. An in vitro study has shown coadministration of deferiprone with phenylbutazone (UGT1A6 inhibitor) decreased glucuronidation to 3-O-glucuronide (the major inactive metabolite of deferiprone) by up to 78%.
MANAGEMENT: The use of deferiprone with UGT1A6 inhibitors should be avoided.
References (1)
- (2011) "Product Information. Ferriprox (deferiprone)." ApoPharma USA Inc
Drug and food/lifestyle interactions
diclofenac food/lifestyle
Applies to: Dyloject (diclofenac)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References (1)
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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