Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Afinitor Disperz (everolimus)
- Lorabid (loracarbef)
Interactions between your drugs
No drug ⬌ drug interactions were found between the drugs in your list. However, this does not necessarily mean no drug interactions exist. Always consult your healthcare provider.
Drug and food interactions
loracarbef food
Applies to: Lorabid (loracarbef)
ADJUST DOSING INTERVAL: Loracarbef may exhibit reduced gastrointestinal absorption in the presence of food. When loracarbef capsules were administered with food, the peak plasma concentrations were 50% to 60% of concentrations after administration in a fasting state and were reached 30 to 60 minutes later. Area under the concentration-time curve (AUC) was not affected. The therapeutic effect of the antimicrobial may be reduced.
MANAGEMENT: Loracarbef should be administered at least one hour before or two hours after eating.
References (1)
- (2002) "Product Information. Lorabid (loracarbef)." Lilly, Eli and Company
everolimus food
Applies to: Afinitor Disperz (everolimus)
GENERALLY AVOID: Grapefruit juice may significantly increase the plasma concentrations of orally administered everolimus. The mechanism is inhibition of CYP450 3A4 and P-glycoprotein activity in the gut wall by certain compounds present in grapefruit.
MANAGEMENT: Patients treated with everolimus should avoid consumption of grapefruit and grapefruit juice.
References (1)
- (2009) "Product Information. Afinitor (everolimus)." Novartis Pharmaceuticals
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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