Drug Interaction Report

Talk to your doctor before using probenecid together with glycerol phenylbutyrate. Probenecid may interfere with the excretion of metabolites of glycerol phenylbutyrate into the urine. Since blood and urine levels of these metabolites may be used to help guide glycerol phenylbutyrate treatment and determine effectiveness, your doctor will need to be aware of this interaction when making any dose adjustments. In addition, you may be at increased risk of developing nervous system side effects associated with one of the metabolites, including drowsiness, lightheadedness, fatigue, headache, taste disturbances, hearing problems, confusion, memory impairment, tremor, and seizures. You should contact your doctor immediately if you experience these or other unusual symptoms. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Information for this minor interaction is available on the professional version.

You may experience reduced absorption of ampicillin in the presence of food. The effectiveness of the antibiotic may be reduced. Ampicillin should be administered one hour before or two hours after meals. This will make it easier for your body to absorb the medication. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.