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Drug Interaction Report

2 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Moderate

naphazoline nasal zavegepant

Applies to: naphazoline / phenylephrine / pyrilamine, zavegepant

ADJUST DOSING INTERVAL: Concomitant use with nasal decongestants may decrease the absorption and pharmacologic effects of intranasal zavegepant. However, pharmacokinetic studies evaluating the effect of concomitant nasal decongestants on intranasal zavegepant are not available.

MANAGEMENT: Concomitant use of nasal decongestants with zavegepant should be avoided. To minimize the risk of interaction, patients who require a nasal decongestant on a day when zavegepant dosing is required should administer the medications at least one hour after administering zavegepant.

References (1)
  1. (2023) "Product Information. Zavzpret (zavegepant)." Pfizer U.S. Pharmaceuticals Group
Moderate

phenylephrine nasal zavegepant

Applies to: naphazoline / phenylephrine / pyrilamine, zavegepant

ADJUST DOSING INTERVAL: Concomitant use with nasal decongestants may decrease the absorption and pharmacologic effects of intranasal zavegepant. However, pharmacokinetic studies evaluating the effect of concomitant nasal decongestants on intranasal zavegepant are not available.

MANAGEMENT: Concomitant use of nasal decongestants with zavegepant should be avoided. To minimize the risk of interaction, patients who require a nasal decongestant on a day when zavegepant dosing is required should administer the medications at least one hour after administering zavegepant.

References (1)
  1. (2023) "Product Information. Zavzpret (zavegepant)." Pfizer U.S. Pharmaceuticals Group

Drug and food interactions

No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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