Skip to main content


Medically reviewed by Last updated on Jul 17, 2023.

Excipient (pharmacologically inactive substance)

What is it?

As an inactive ingredient, tromethamine (C4H11NO3) is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. Tromethamine as a pharmaceutical agent is used to treat metabolic acidosis (an electrolyte imbalance). Metabolic acidosis can have many causes. It often occurs after heart bypass surgery or cardiac arrest.[1][2]

List of medications using Tromethamine


  1. Tromethamine. Accessed February 14, 2015 at
  2. PubChem. Tromethamine. Accessed February 14, 2105 at

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.