Excipient (pharmacologically inactive substance)
Medically reviewed by Drugs.com. Last updated on Feb 27, 2019.
What is it?
Also known as 1',4,6'-trichlorogalactosucrose, trichlorosucrose, or brand name Splenda with a molecular formula of C12H19Cl3O8, sucralose is about 600 times sweeter than sugar. Sucralose is a low-calorie sweetening agent used in beverages, foods, medications. High-intensity sweeteners are commonly used as sugar substitutes or sugar alternatives because they are many times sweeter than sugar but contribute only a few to no calories when added to foods. High-intensity sweeteners, like all other ingredients added to food in the United States, must be safe for consumption. The starting material for the synthesis of sucralose is sucrose (sugar), but then the structure is synthetically altered to achieve the sucralose compound. According to the FDA, sucralose is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient. Sucralose has been extensively studied and more than 110 safety studies were reviewed by FDA in approving the use of sucralose as a general purpose sweetener for food. However, there have been reports of headaches/migraine attacks occurring in people during sucralose use, as with other artificial sweeteners. Studies support the conclusion that sucralose consumption does not adversely affect short-term blood glucose control in patients with diabetes.
 FDA. Food. Additional Information about High-Intensity Sweeteners Permitted for use in Food in the United States. Accessed February 12, 2015 at http://www.fda.gov/Food/IngredientsPackagingLabeling/FoodAdditivesIngredients/ucm397725.htm
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Top Medications with this excipient
- Acetaminophen 500 mg
- Acetaminophen Junior Strength (Chewable) 160 mg
- Alprazolam (orally disintegrating) 0.25 mg
- Buprenorphine Hydrochloride and Naloxone Hydrochloride (Sublingual) 8 mg (base) / 2 mg (base)
- Buprenorphine Hydrochloride and Naloxone Hydrochloride (Sublingual) 2 mg (base) / 0.5 mg (base)
- Donepezil Hydrochloride (Orally Disintegrating) 5 mg
- Duract Max Strength Cough dextromethorphan hydrobromide 30mg
- Lamotrigine (Chewable, Dispersible) 25 mg
- Multivitamin with Fluoride (Chewable) multivitamin with fluoride 1 mg
- Nephrocaps QT multiple vitamins
- Olanzapine (Orally Disintegrating) 15 mg
- Ranitidine Hydrochloride 150 mg
- Simvastatin (Orally Disintegrating) 40 mg
- Sodium Fluoride (Chewable) 2.2 mg (equiv. fluoride 1 mg)
- Suprenza 30 mg
- Tylenol Sinus + Headache Day acetaminophen 325 mg / phenylephrine hydrochloride 5 mg
- V-Natal prenatal multivitamins with folic acid 1 mg
- Viva CT Prenatal Multivitamins with Folic Acid 1 mg
- Zenchent Fe ethinyl estradiol 0.035 mg / norethindrone 0.4 mg
- Zeosa ethinyl estradiol 0.035 mg / norethindrone 0.4 mg