Sorbitol

Medically reviewed by Drugs.com. Last updated on Apr 28, 2025.

Excipient (pharmacologically inactive substance)

What is it?

Sorbitol (C6H14O6) is a sugar alcohol (polyol) used in the pharmaceutical, cosmetic and food industry as a sweetener or humectant (for protection against loss of moisture content). It is produced by hydrogenation of glucose and is available in liquid and crystalline form. It also occurs naturally in many fresh fruits and berries. Sorbitol is also found commonly in "sugar-free" chewing gum, and may be used to sweeten pharmaceutical dosage forms such as syrups or chewable tablets.

Excessive consumption of sorbitol may lead to a laxative effect, but the small amount used in pharmaceutical manufacturing processes would not normally pose this risk.

Sorbitol is about two-thirds as sweet as glucose. It has a lower calorie content than glucose and may be used in diabetic foods. Sorbitol has roughly 2.6 calories per gram of bulk product. Sorbitol in normal quantities is a safe food product for consumption, and is listed in the FDA’s Generally Regarded as Safe GRAS listing. ^{[1] [2]}

Some examples of medications containing Sorbitol

• Advil Liqui-Gels 200 mg
• Amitiza 8 mcg
• Backaid Max acetaminophen 500 mg / pamabrom 25 mg
• Benzonatate 100 mg
• Colace 100 mg
• Diphenhydramine Hydrochloride 50 mg
• Docusate Sodium 100 mg
• Docusate Sodium 100 mg
• Docusate Sodium 100mg
• Dramamine For Kids (Chewable) dimenhydrinate 25 mg
• Hyoscyamine Sulfate (Sublingual) 0.125 mg
• Ibuprofen 200 mg
• Ibuprofen 200 mg
• Lithium Carbonate Extended Release 300 mg
• Ondansetron Hydrochloride (Orally Disintegrating) 4 mg
• Simethicone 125 mg
• Simethicone (Chewable) 80 mg
• Simethicone (Chewable) 80 mg
• Staxyn 10 mg
• Zephrex-D 30 mg

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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