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Silicon Dioxide

Medically reviewed by Last updated on Jun 26, 2023.

Excipient (pharmacologically inactive substance)

What is it?

Silicon dioxide (SiO2), or silica, is known in nature as sand or quartz. It occurs naturally in the earth’s crust, and silicates are present in water, animals and plants. Silicates are also consumed as part of the natural human diet.

In the pharmaceutical industry, silicon dioxide (also known as colloidal silicon dioxide) has many uses in tablet-making, including as an anti-caking agent, adsorbent, disintegrant, or glidant to allow powder to flow freely when tablets are processed. These compounds appear to be biologically inert. Silicon dioxide is generally recognized as safe by the FDA.[1][2]

List of medications using Silicon Dioxide


  1. [1]Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 Accessed 08/19/2011
  2. FDA’s SCOGS database; Silicon dioxides, Report No. 61, 1979.; ID Code: 14808-60-7;; accessed August 12, 2011.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.