Excipient (pharmacologically inactive substance)
What is it?
Propylparaben has been used as an antimicrobial preservative in the food, cosmetic, and pharmaceutical industries for over 50 years. The chemical formula for propylparaben is C10H12O3.
Propylparaben is easily absorbed through the gastrointestinal tract and skin, and metabolites are rapidly excreted in the urine. It does not appear to accumulate in the body. It is on the FDA generally regarded as safe list.
Animal toxicity studies suggest propylparaben is relatively nontoxic by both the oral and injectable routes, but may irritate the skin It has not been shown to be carcinogenic, mutagenic or clastogenic. All parabens have similar structure to estrogen. Studies conducted in the early 2000s located traces of parabens in breast tumors, but evidence has not linked parabens with breast cancer.
The Cosmetic Ingredient Review (CIR) reviewed the safety of methylparaben, propylparaben, and butylparaben in 1984 and concluded they were safe for use in cosmetic products at levels up to 25%. Typically parabens are used at levels ranging from 0.01 to 0.3%.
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008. Accessed 08/17/2011. http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047
Top Medications with this excipient
- Acetaminophen 325 mg
- Anafranil 50 mg
- Benzonatate 100 mg
- Bisacodyl 5 mg
- Chlordiazepoxide Hydrochloride 10 mg
- Chlordiazepoxide Hydrochloride and Clidinium Bromide 5 mg / 2.5 mg
- Chlorpromazine Hydrochloride 50 mg
- Chlorpromazine Hydrochloride 200 mg
- Cyclobenzaprine Hydrochloride 10 mg
- Lescol 40 mg
- Lopid 600 mg
- Oxazepam 10 mg
- Phenytoin Sodium Extended 100 mg
- Phrenilin Forte acetaminophen 650mg / butalbital 50mg
- Temazepam 15 mg
- Theophylline Extended-Release 125 mg
- Tofranil-PM 150 mg
- Vimovo esomeprazole 20 mg / naproxen 500 mg
- Vimovo esomeprazole 20 mg / naproxen 375 mg
- Zenatane 10 mg