Excipient (pharmacologically inactive substance)
Medically reviewed by Drugs.com. Last updated on Oct 2, 2018.
What is it?
Propylparaben has been used as an antimicrobial preservative in the food, cosmetic, and pharmaceutical industries for over 50 years. The chemical formula for propylparaben is C10H12O3.
Propylparaben is easily absorbed through the gastrointestinal tract and skin, and metabolites are rapidly excreted in the urine. It does not appear to accumulate in the body. It is on the FDA generally regarded as safe list.
Animal toxicity studies suggest propylparaben is relatively nontoxic by both the oral and injectable routes, but may irritate the skin It has not been shown to be carcinogenic, mutagenic or clastogenic. All parabens have similar structure to estrogen. Studies conducted in the early 2000s located traces of parabens in breast tumors, but evidence has not linked parabens with breast cancer.
The Cosmetic Ingredient Review (CIR) reviewed the safety of methylparaben, propylparaben, and butylparaben in 1984 and concluded they were safe for use in cosmetic products at levels up to 25%. Typically parabens are used at levels ranging from 0.01 to 0.3%.
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008. Accessed 08/17/2011. http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047
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Top Medications with this excipient
- Acetaminophen 500 mg
- Acetaminophen 325 mg
- Benzonatate 100 mg
- Benzonatate 200 mg
- Chlorpromazine Hydrochloride 100 mg
- Chlorpromazine Hydrochloride 50 mg
- Dipyridamole 25 mg
- Ethosuximide 250 mg
- Imipramine Pamoate 75 mg
- Imipramine Pamoate 150 mg
- Loxapine Succinate 5 mg
- Methergine 0.2 mg
- Nifedipine 10 mg
- Nortriptyline Hydrochloride 10 mg
- Nortriptyline Hydrochloride 25 mg
- Oxazepam 30 mg
- Oxsoralen-ultra 10 mg
- Tetracycline Hydrochloride 500 mg
- Tums Chewy Bites calcium carbonate 750 mg
- Tylenol Extra Strength 500 mg