Excipient (pharmacologically inactive substance)
Medically reviewed by Drugs.com. Last updated on Sep 22, 2020.
What is it?
Propylparaben has been used as an antimicrobial preservative in the food, cosmetic, and pharmaceutical industries for over 50 years. The chemical formula for propylparaben is C10H12O3.
Propylparaben is easily absorbed through the gastrointestinal tract and skin, and metabolites are rapidly excreted in the urine. It does not appear to accumulate in the body. It is on the FDA generally regarded as safe list.
Animal toxicity studies suggest propylparaben is relatively nontoxic by both the oral and injectable routes, but may irritate the skin It has not been shown to be carcinogenic, mutagenic or clastogenic. All parabens have similar structure to estrogen. Studies conducted in the early 2000s located traces of parabens in breast tumors, but evidence has not linked parabens with breast cancer.
The Cosmetic Ingredient Review (CIR) reviewed the safety of methylparaben, propylparaben, and butylparaben in 1984 and concluded they were safe for use in cosmetic products at levels up to 25%. Typically parabens are used at levels ranging from 0.01 to 0.3%.
Top Medications with this excipient
- Acetaminophen 325 mg
- Acetaminophen 500 mg
- Advil 200 mg
- Alka-Seltzer Fruit Chews (Antacid) calcium carbonate 750 mg
- Amantadine Hydrochloride 100 mg
- Anafranil 50 mg
- Benzonatate 100 mg
- Ceftin 250 mg
- Chlordiazepoxide Hydrochloride 5 mg
- Chlorpromazine Hydrochloride 100 mg
- Cough & Cold chlorpheniramine maleate 4 mg / dextromethorphan hydrobromide 30 mg
- Disopyramide Phosphate 100 mg
- Lescol 40 mg
- Librium 5 mg
- Librium 10 mg
- Methoxsalen 10 mg
- Phenytoin Sodium Extended 100 mg
- Temozolomide 20 mg
- Tylenol Extra Strength 500 mg
- Verapamil Hydrochloride SR 240 mg
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008. Accessed 08/17/2011. http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.