Excipient (pharmacologically inactive substance)
What is it?
Propylparaben has been used as an antimicrobial preservative in the food, cosmetic, and pharmaceutical industries for over 50 years. The chemical formula for propylparaben is C10H12O3.
Propylparaben is easily absorbed through the gastrointestinal tract and skin, and metabolites are rapidly excreted in the urine. It does not appear to accumulate in the body. It is on the FDA generally regarded as safe list.
Animal toxicity studies suggest propylparaben is relatively nontoxic by both the oral and injectable routes, but may irritate the skin It has not been shown to be carcinogenic, mutagenic or clastogenic. All parabens have similar structure to estrogen. Studies conducted in the early 2000s located traces of parabens in breast tumors, but evidence has not linked parabens with breast cancer.
The Cosmetic Ingredient Review (CIR) reviewed the safety of methylparaben, propylparaben, and butylparaben in 1984 and concluded they were safe for use in cosmetic products at levels up to 25%. Typically parabens are used at levels ranging from 0.01 to 0.3%.
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008. Accessed 08/17/2011. http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047
Top Medications with this excipient
- Acetaminophen 325 mg
- Advil 200 mg
- Advil cold sinus 200 mg / 30 mg
- Advil Junior Strength 100 mg
- Benzonatate 100 mg
- Chlordiazepoxide Hydrochloride 5 mg
- Cyclobenzaprine Hydrochloride 10 mg
- Diphenhist 25 mg
- Diphenhydramine Hydrochloride 25 mg
- Docusate Calcium 240 mg
- Matulane 50 mg
- Nifedipine 10 mg
- Nortriptyline Hydrochloride 25 mg
- Nortriptyline Hydrochloride 75 mg
- Piroxicam 20 mg
- Piroxicam 10 mg
- Rocaltrol 0.5 mcg
- Surmontil 50 mg
- Valproic Acid 250 mg
- Vimovo esomeprazole 20 mg / naproxen 500 mg