Excipient (pharmacologically inactive substance)
What is it?
Starches are typically derived from corn or potato. Starches are used in the pharmaceutical industry for a wide variety of reasons, such as an excipient, a tablet and capsule diluent, a tablet and capsule disintegrant, a glidant, or as binder. Disintegrants enable tablets and capsules to break down into smaller fragments (dissolve) so that the drug can be released for absorption. Starches also absorb water rapidly, allowing tablets to disintegrate appropriately.
Starches are also used in the food manufacturing industry for processing, and as food thickeners or stabilizers. There are many other diverse uses for starches in the manufacturing industry. Pregelatinized starch derives primarily from corn, has been cooked and then dried. Instant puddings, pie fillings, soup mixes, salad dressings, candy often contain pregelatinized starch.
Pregelatinized starches (dried, cooked starches) are highly digestible. Consumption of excessive quantities of raw starch has resulted in obesity and iron-deficiency anemia in human subjects. However, there is no evidence to suspect a hazard to the public when starches are used at levels that are now current or that might reasonably be expected in the future; indeed they are consumed daily in most diets.
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
Top Medications with this excipient
- Baclofen 10 mg (Northstar Rx LLC)
- Captopril 100 mg (West-Ward Pharmaceutical Corporation)
- Captopril 12.5 mg (West-Ward Pharmaceutical Corporation)
- Chloroquine Phosphate 250 mg (Global Pharmaceuticals)
- DDAVP 0.1 MG (Sanofi-Aventis)
- Desmopressin Acetate 0.1 mg (Ferring Pharmaceuticals Inc.)
- Fluvoxamine Maleate 25 mg (BayPharma, Inc.)
- Fluvoxamine Maleate 100 mg (BayPharma, Inc.)
- Fluvoxamine Maleate 50 mg (BayPharma, Inc.)
- Imuran 50 mg (Prometheus Laboratories Inc.)
- Lanoxin 250 mcg (0.25 mg) (GlaxoSmithKline)
- Methimazole 5 mg (URL Pharma)
- Methimazole 10 mg (URL Pharma)
- Plan B 0.75 mg (Duramed Pharmaceuticals, Inc.)
- Plan B One Step levonorgestrel 1.5 mg (Teva Pharmaceuticals USA)
- Prednisone 10 mg (Cadista)
- Prednisone 20 mg (Cadista)
- Prednisone 5 mg (Cadista)
- THIOGUANINE 40 MG (GSK Pharm)
- Viorele desogestrel 0.15 mg / ethinyl estradiol 0.02 mg (Glenmark Generics Inc., USA)