Polyethylene Glycol 8000
Excipient (pharmacologically inactive substance)
Medically reviewed by Drugs.com. Last updated on February 19, 2021.
What is it?
Polyethylene glycol, referred to as PEG, is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointments and suppository base, and tablet and capsule lubricant. PEG has low toxicity with systemic absorption less than 0.5%.
PEGylation occurs when PEGs are attached to various protein medications, allowing for greater solubility for certain drugs. Examples of PEGylated medications include PEG-interferon alpha (Pegintron) and PEG-filgrastim (Neulasta). PEG is also available as a bowel prep for colonoscopy procedures and as a laxative.
PEG 400 indicates the average molecular weight of the specific PEG at 400. PEG 3350 is a laxative available over-the-counter by the name of Miralax. In this case, PEG is considered an "active" ingredient, even though systemic absorption is less than 0.5%.
Top Medications with this excipient
- Alogliptin Benzoate and Pioglitazone Hydrochloride 12.5 mg / 30 mg
- Alogliptin Benzoate and Pioglitazone Hydrochloride 25 mg / 45 mg
- Amitriptyline Hydrochloride 25 mg
- Amoxicillin Trihydrate 875 mg
- Amoxicillin Trihydrate 500 mg
- Atorvastatin Calcium 10 mg
- Atorvastatin Calcium 20 mg
- Atorvastatin Calcium 40 mg
- Cenestin synthetic conjugated estrogens, A 0.45 mg
- Cyclobenzaprine Hydrochloride 10 mg
- Demeclocycline Hydrochloride 300 mg
- Diovan 320 mg
- Etodolac ER 500 mg
- Hydroxyzine Hydrochloride 50 mg
- Hydroxyzine Hydrochloride 25 mg
- Mono-Linyah ethinyl estradiol 0.035 mg / norgestimate 0.25 mg
- Olanzapine 5 mg
- Pravastatin Sodium 20 mg
- Spironolactone Hydrochloride 25 mg
- Zolpidem Tartrate 10 mg
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
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