Polyethylene Glycol 8000
Excipient (pharmacologically inactive substance)
What is it?
Polyethylene glycol, referred to as PEG, is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointments and suppository base, and tablet and capsule lubricant. PEG has low toxicity with systemic absorption less than 0.5%.
PEGylation occurs when PEGs are attached to various protein medications, allowing for greater solubility for certain drugs. Examples of PEGylated medications include PEG-interferon alpha (Pegintron) and PEG-filgrastim (Neulasta). PEG is also available as a bowel prep for colonoscopy procedures and as a laxative.
PEG 400 indicates the average molecular weight of the specific PEG at 400. PEG 3350 is a laxative available over-the-counter by the name of Miralax. In this case, PEG is considered an "active" ingredient, even though systemic absorption is less than 0.5%.
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
Top Medications with this excipient
- Amoxicillin and Clavulanate Potassium 500 mg / 125 mg
- Amoxicillin Trihydrate 875 mg
- Anaprox DS naproxen sodium 550 mg
- Atorvastatin Calcium 40 mg
- Atorvastatin Calcium 10 mg
- Atorvastatin Calcium 20 mg
- Ciprofloxacin Hydrochloride 250 mg
- Clopidogrel Bisulfate 75 mg (base)
- Donepezil Hydrochloride 5 mg
- Gabapentin 600 mg
- Hydrocodone Bitartrate and Ibuprofen 7.5 mg / 200 mg
- Lipofen 150 mg
- Metoprolol Succinate Extended-Release 50 mg
- Metoprolol Succinate Extended-Release 25 mg
- Naproxen Sodium 550 mg
- Norpramin 50 mg
- Quetiapine Fumarate 50 mg
- Spironolactone Hydrochloride 25 mg
- Urso Forte 500 mg
- Zolpidem Tartrate 10 mg