Poloxamer 188
Medically reviewed by Drugs.com. Last updated on Apr 17, 2025.
Excipient (pharmacologically inactive substance)
What is it?
Poloxamers are polymers used for drug delivery as formulation excipients. They are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. They are also used in topical dosage forms and rectal suppositories. The common available grades are poloxamer 68, 88, 98, 108, 124, 188, 237, 338, and 407.[1]
Some examples of medications containing Poloxamer 188
- Alprazolam Extended Release 2 mg
- Atovaquone and Proguanil Hydrochloride 250 mg / 100 mg
- Atovaquone and Proguanil Hydrochloride 250 mg / 100 mg
- Benazepril Hydrochloride and Hydrochlorothiazide 20 mg / 12.5 mg
- Benazepril Hydrochloride and Hydrochlorothiazide 10 mg / 12.5 mg
- Envarsus XR 1 mg
- Glimepiride 2 mg
- Glimepiride 4 mg
- Glimepiride 1 mg
- Itraconazole 100 mg
- Lovastatin 20 mg
- Malarone 250 mg / 100 mg
- Metoprolol Succinate Extended-Release 100 mg
- Metoprolol Succinate Extended-Release 50 mg
- Metoprolol Succinate Extended-Release 25 mg
- Repaglinide 0.5 mg
- Repaglinide 1 mg
- Sirolimus 0.5 mg
- Valsartan 80 mg
- Valsartan 160 mg
References
- Patel, HR, et al. Poloxamers: A pharmaceutical excipients with therapeutic behaviors. International Journal of PharmTech Research. Vol.1, No.2, pp 299-303 , April-June 2009. Accessed February 27, 2015 at http://www.sphinxsai.com/pdf/jpt_Ap_Ju_09/PT=35%20%20Rakesh%20Patel%20%28299-303%29.pdf
Further information
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