Microcrystalline Cellulose
Medically reviewed by Drugs.com. Last updated on Aug 28, 2024.
Excipient (pharmacologically inactive substance)
What is it?
Microcrystalline cellulose (C6H10O5)n is refined wood pulp. It is a white, free-flowing powder. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. In large quantities it provides dietary bulk and may lead to a laxative effect.
Microcrystalline cellulose is a commonly used excipient in the pharmaceutical industry. It has excellent compressibility properties and is used in solid dose forms, such as tablets. Tablets can be formed that are hard, but dissolve quickly. Microcrystalline cellulose is the same as cellulose, except that it meets USP standards.[1]
It is also found in many processed food products, and may be used as an anti-caking agent, stabilizer, texture modifier, or suspending agent among other uses. According to the Select Committee on GRAS Substances, microcrystalline cellulose is generally regarded as safe when used in normal quantities. [2][3][4]
Some examples of medications containing Microcrystalline Cellulose
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 10 mg
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 5 mg
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 7.5 mg
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 10 mg
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 10 mg
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 10 mg
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 5 mg
- Alprazolam 1 mg
- Alprazolam 2 mg
- Alprazolam 0.5 mg
- Amphetamine and Dextroamphetamine 30 mg
- Cyclobenzaprine Hydrochloride 10 mg
- Lortab 10/325 325 mg / 10 mg
- Oxycodone Hydrochloride 30 mg
- Oxycodone Hydrochloride 10 mg
- Oxycodone Hydrochloride 10 mg
- Oxycodone Hydrochloride 5 mg
- Oxycodone Hydrochloride 5 mg
- Tramadol Hydrochloride 50 mg
- Trazodone Hydrochloride 50 mg
References
- [1]Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
- FDA’s SCOGS database; Microcrystalline cellulose, Report No. 25, 1979.; ID Code: 9004-57-3; Accessed July 28, 2011.
- Food and Agricultural Organization of the United Nations. Corporate Document Repository. Compendium of Food Additive Specifications, Addendum 5. Microcrystalline cellulose. http://www.fao.org/docrep/W6355E/w6355e0l.htm Accessed July 28, 2011
- US Dept of Agriculture, Agricultural Marketing Service. Cellulose processing. Executive Summary. Accessed 7/28/2011.
Further information
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