Excipient (pharmacologically inactive substance)
Medically reviewed by Drugs.com. Last updated on Sep 15, 2018.
What is it?
Methylparaben has been used as a preservative in the food, cosmetic, and pharmaceutical industries for over 50 years. The chemical formula for methyl paraben is C8H8O3. It is also found naturally in fruits like blueberries where it has antimicrobial activity.
Methylparaben is completely absorbed through the skin or after ingestion, and it is hydrolyzed to para-hydroxybenzoic acid, and metabolites are rapidly excreted in the urine. There is no evidence of accumulation. It is on the FDA generally regarded as safe list.
Acute toxicity studies in animals indicate that methylparaben is practically non-toxic by both oral and injectable routes. It has not been shown to be teratogenic, carcinogenic, mutagenic or embryotoxic.
It does not appear to be irritating when used topically, although some people may show cross-sensitivity if allergic to local anesthetics that are metabolized to para-aminobenzoic acid. Cases of local contact dermatitis have been reported. All parabens have similar structure to estrogen. Studies conducted in the early 2000s located traces of parabens in breast tumors, but evidence has not linked parabens with breast cancer.
The Cosmetic Ingredient Review (CIR) reviewed the safety of methylparaben, propylparaben, and butylparaben in 1984 and concluded they were safe for use in cosmetic products at levels up to 25%. Typically parabens are used at levels ranging from 0.01 to 0.3%.
 Soni MG, Taylor SL, Greenberg NA, et al. Evaluation of the health aspects of methyl paraben: a review of the published literature. Food Chem. Toxicol. 40:1335-73. Accessed 8/17/2012 http://www.sciencedirect.com/science/article/pii/S0278691502001072
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Top Medications with this excipient
- Acetaminophen 325 mg
- Acetaminophen, Diphenhydramine Hydrochloride and Phenylephrine Hydrochloride 325 mg / 12.5 mg / 5 mg
- Ancobon 500 mg
- Benzonatate 100 mg
- Bisacodyl 5 mg
- Chlorpromazine Hydrochloride 25 mg
- Cyclobenzaprine Hydrochloride 10 mg
- Diphenhydramine Hydrochloride 25 mg
- Lescol 20 mg
- Methylergonovine Maleate 0.2 mg
- Morphine Sulfate Extended-Release 15 mg
- Morphine Sulfate Extended-Release 30 mg
- Opana ER 7.5 mg
- Phrenilin Forte acetaminophen 650mg / butalbital 50mg
- Rocaltrol 0.5 mcg
- Sennosides 15 mg
- St. Joseph HBP Cough & Cold chlorpheniramine maleate 4 mg / dextromethorphan hydrobromide 30 mg
- Temazepam 30 mg
- Vimovo esomeprazole 20 mg / naproxen 500 mg
- Zenatane 40 mg