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Hypromellose 2910 3cp

Excipient (pharmacologically inactive substance)

Medically reviewed by Last updated on Jul 23, 2020.

What is it?

Hypromellose, also commonly known as hydroxypropyl methycellulose (HPMC) is a coating agent and film-former used as an inactive ingredient in the pharmaceutical industry.[1] It has also been used as a rate-controlling polymer for sustained-release dose forms.

As a powder, hypromellose is off-white to beige and may be in granules. Hypromellose is considered an inert ingredient. It has a high viscosity and is often used in ophthalmic preparations as artificial tears for dry eyes.[2] In the US, it is available over-the-counter (OTC) in such products as Isopto Tears and Nature’s Tears.

Hypromellose per the USP specifies the substitution type by adding a number to the nonproprietary name: e.g. hypromellose 2910. The first two digits refer to the approximate percent content of the methoxy group (OCH3). The second two digits refer to the approximate percent content of the hydroxypropoxy group (OCH2CH(OH)CH3), calculated on a dried basis. These are large molecules with molecular weights ranging from approximately 10000–1,500,000.[3]


[1] [1]Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 Accessed 08/19/2011

[2] Innovate Us. What is Hypromellose? Accessed 08/19/2011

[3] Medicines Complete. Pharmaceutical Excipients. Monographs. Hypromellose. Accessed April 16, 2012.

Further information

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