Excipient (pharmacologically inactive substance)
What is it?
Glycerin (C3H8O3), also known as glycerol and glycerine, is an odorless, colorless, oily, viscous liquid that has a sweet taste.
Synthetic glycerin is used in food products, nutritional supplements, pharmaceutical products, personal-care products, and oral-care products. In the pharmaceutical industry, glycerin is used as a sweetener in syrups, lozenges, and as an excipient in eyewash solutions. It my also be found in eardrop products, jellies and creams for topical use, in expectorants for congestion, suppositories, and gel capsules.
As an individual prescription product, glycerin has uses as a hyperosmotic, osmotic diuretic, and ophthalmic agent. It may be used as eye drop in the treatment of glaucoma to reduce intraocular pressure, as a solution or suppository for short-term treatment of constipation, to evacuate the bowel prior to colonoscopy, and in some ocular surgeries. It may be given intravenously to reduce pressure inside the brain, and used externally on the skin as a moisturizer. Glycerin has many other uses in the agricultural, food and pharmaceutical industry.
The U.S. Food and Drug Administration (FDA) classify glycerin as “generally recognized as safe” (GRAS). The overall risk of toxicity from glycerin found in pharmaceutical products is low. If one were to come into contact with large, bulk quantities of glycerin, eye irritation may occur. Skin irritation is unlikely unless the skin is damaged where contact occurs. Inhalational toxicity is low due to low volatility, but prolonged, excessive ingestion can cause elevated blood sugar or fat levels in the blood.
 Dow Chemical. Glycerine. Product Safety Assessment. Accessed April 14, 2012. http://msdssearch.dow.com/PublishedLiteratureDOWCOM/dh_01ad/0901b803801ade92.pdf?filepath=productsafety/pdfs/noreg/233-00490.pdf&fromPage=GetDoc
Top Medications with this excipient
- Amnesteem 10 mg (Mylan Pharmaceuticals Inc.)
- Benzonatate 100 mg (Major Pharmaceuticals Inc.)
- Citalopram Hydrobromide 20 mg (Amneal Pharmaceuticals)
- Citalopram Hydrobromide 40 mg (Amneal Pharmaceuticals)
- Clonidine Hydrochloride 0.1 mg (Unichem Pharmaceuticals)
- Clonidine Hydrochloride 0.2 mg (Unichem Pharmaceuticals)
- Diphenhydramine Hydrochloride 25 mg (P and L Development of New York Corporation)
- Doc-Q-Lace docusate 100 mg (Qualitest Pharmaceuticals Inc.)
- Docusate Calcium 240 mg (Cardinal Health)
- Dronabinol 2.5 mg (Par Pharmaceutical Inc.)
- Fluoxetine Hydrochloride 60 mg (Edgemont Pharmaceuticals, LLC)
- Folcal DHA prenatal multivitamins with folic acid 1.25 mg and docusate sodium 55 mg (Midlothian Laboratories LLC)
- Natelle One DHA Prenatal Multivitamins with Folic Acid 1 mg (Azur Pharma Inc)
- Nifedipine 10 mg (Heritage Pharmaceuticals Inc.)
- Nifedipine 20 mg (Heritage Pharmaceuticals Inc.)
- Nimodipine 30 mg (Heritage Pharmaceuticals, Inc.)
- Relnate DHA prenatal multivitamins with folic acid 1 mg (Burel Pharmaceuticals)
- Taron-PRX Plus DHA Prenatal Multivitamins with Folic Acid 1.24 mg and Docusate (Trigen Laboratories Inc)
- Valproic Acid 250 mg (UDL Laboratories Inc)
- Valproic Acid 250 mg (Sun Pharmaceutical Industries Limited)